The long-term use of complete maxillary dentures in the presence of natural residual anterior teeth may cause degenerative changes in the masticatory organ that are classified as signs of Kelly’s syndrome and pose a considerable reconstructive challenge. Failure to provide the patient with proper restorations aggravates destruction in the oral cavity, which is manifested as functional disorders and visible in the patient’s facial appearance. The aim of this paper is to present corrective procedures to be conducted before final prosthetic rehabilitation. The authors discuss the steps that need to be taken in the case of particular pathological symptoms linked with Kelly’s syndrome. The possibilities of prosthetic management with the use of conventional removable dentures and/or the application of intraosseous implants to optimize prosthetic treatment and prevent the destruction of the prosthetic base are also presented.