IntroductionRapid spread of COVID-19 has caused detrimental effect globally. Involvement of ACE2 receptor has identified COVID-19 as a multi-organ disease. Preliminary studies have provided evidence that cardiac involvement, including right ventricular dysfunction (RVD) and pulmonary hypertension (PH) were found in COVID-19 cases, even in the non-advanced stage. This meta-analysis aims to analyze the prevalence of RVD and PH, and its association with COVID-19 clinical outcome.Material and methodsA systematic data search was conducted through PubMed, MedRxiv, ProQuest, Science Direct, and Scopus databases using constructed keywords based on MeSH terms. Any outcomes regarding mortality, severity, ICU admission, and mechanical ventilation usage were analyzed using Revman v.5.4 and Stata v.16.ResultsA total of 16 eligible studies (1,728 patients) were included. Pooled prevalence of RVD in COVID-19 was 19% (95%CI: 13%−25%), and PH was 22% (95% CI: 14%-31%). RVD was associated with increased mortality (OR=2.98 [95%CI: 1.50-5.89], p=0.002), severity (OR= 3.61 [95%CI: 2.05−6.35], p<0.001), ICU admission (OR= 1.70 [95%CI: 1.12−2.56], p=0.01), and mechanical ventilation (MV) usage (OR= 1.60 [95%CI: 1.14−2.25], p=0.007). PH was also associated with increased mortality (OR=5.42 [95%CI: 2.66-11.06], p<0.001), severity (OR=5.74 [95%CI: 2.28-14.49], p<0.001), and ICU admission (OR: 12.83 [95% CI: 3.55-46.41], p<0.001).ConclusionsRVD and PH were prevalent in COVID-19 and associated with mortality, severity, ICU admission, and MV usage in COVID-19 patients. Bedside echocardiography examination could be considered as a novel risk stratification tool in COVID-19.

Background Coronary heart disease is a deadly disease for both men and women. Risk factors for coronary heart disease include age, sex, hypertension, diabetes mellitus, dyslipidemia. The incidence of coronary heart disease is not uniform thus here we reported the profile of coronary heart disease patients in Soetomo General Hospital Objective To analyze the profile of coronary heart disease patients in RSUD dr. Soetomo from February 2018 until September 2018. Materials and Methods A descriptive research based on the medical records patients was done Result There are 65 male patients (76%) and 20 female patients (24%). There are 58% patients aged 50-60 years (49 people), 24% patients aged more than 60 years old (21 people) and 18% patients less than 50 years old (15 people). Types of patients' occupations include 42% public servants (36 people), 36% private employees (31 people), 9% housewives (8 people), 5% retirees (3 people), 3% entrepreneurs (2 people), 1% teachers (1 person), 1% drivers (1 person) , 1% fishermen (1 person), 1% pastor (1 person) 1% merchant (1 person). The main complaints of patients included chest pain (40% or 34 cases), shortness of breath (23.5% or 20 cases),PCI pro staging therapy (4.6% or 4 cases), thump chest (1.2% or 1 case), lower right abdominal pain (1.2% or 1 case), right leg pain (1.2% or 1 case), nausea (1.2% or 1 case), vomiting (1.2% or 1 case), cough (1.2% or 1 case), dysentery (1.2% or 1 case) and no complaints (23.5% or 20 cases). Inpatients with coronary heart disease in Dr. Soetomo General Hospital have a history of hypertension (30.6% or 38 people), heart disease (22.6% or 28 people), diabetes mellitus (21.9% or 26 people), smoking (5.6% or 7 people), dyslipidemia (3.2% or 4 people), stroke (2.4% or 3 people) ), pulmonary TB (0.8% or 1 person), COPD (0.8% or 1 person) and no history of disease (12.9% or 16 people). Fifty-two patients had blood sugar levels of ≥100 mg / dl with a data percentage of 61%. While 16 other patients had blood sugar levels <100 mg / dl with a data percentage of 19%. And the remaining 17 patients did not get data with a percentage of 20% Conclusion We found 85 patients, predominantly males of 50-60 age group. The commonest occupation of these patients is public servant, and they came with major complaints of chest pain with past history of hypertension and high blood levels.

BackgroundWomen with a history of preeclampsia are twice as likely to experience long term cardiovascular disease (CVD) compared to women with unaffected pregnancy. The pathophysiology of preeclampsia is not well understood, however there is general agreement that, similar to cardiovascular disease, endothelial dysfunction plays a crucial role. On a clinical level, preeclampsia and atherosclerotic cardiovascular disease share common risk factors. Carotid intima media thickness (CIMT) is ultrasound-based imaging, non-invasive, simple and reproducible method of subclinical atherosclerosis evaluation. Nowadays, there were studies concerning of CIMT among preeclamptic women, although the results were different.ObjectiveTo prove that CIMT among women with histories of preeclampsia was greater compared to normal pregnancy.MethodsWe conducted a meta-analysis of studies that reported CIMT, in women who had preeclampsia and had normal pregnancy. Studies were identified through three databases: PubMed, Google Scholar dan SAGE Journals with publication year of 2010- 2020. Heterogeneity was assessed using the I2 statistic. Standardized mean difference was used as measured of effect size.ResultsNine eligible studies were included in the meta-analysis. This meta-analysis consisted of 439 women with preeclampsia histories and 526 women with normal pregnancy histories. Women who had preeclampsia had significantly higher CIMT compared to those with normal pregnancy with standardized mean difference −0.38 and 95% confidence interval (CI) −0.68 to −0.07 (p=0.02).ConclusionCIMT was greater among women with histories of preeclampsia compared to normal pregnancy.Prospero registration numberID 228825.

Introduction: European System for Cardiac Operative Risk Evaluation (EuroSCORE) is a scoring system to predict mortality risk after cardiac surgery. EuroSCORE II was introduced to replace and show superiority over EuroSCORE I which tends to overestimate the risk of heart surgery procedures and have a low discrimination ability. Meanwhile, this is the first study to analyze EuroSCORE II as a predictor of mortality and morbidity in Indonesians. Objective: This study aims to analyze EuroSCORE II as a predictor of mortality and morbidity in Indonesians. Materials and Methods: This is a retrospective study using medical records of CABG patients in Dr. Soetomo General Academic Hospital from January 2016 to December 2017. Results and Discussion: Out of 39 Patients who have performed CABG surgery, most were male (89.7%) with the highest age range of 46-65 years (59%). Deceased patients had an average EuroSCORE II of 22.36% and SD±26.97%7%, while 27 patients who survived had an average EuroSCORE II of 6.78% and SD±6.4%. Based on morbidity assessment, EuroSCORE II only accurately predicted the risk of kidney failure and did not properly assess the length of inotropic use, vasopressors, hospitalization time, the risk of arrhythmias, low cardiac output syndrome, Durante-operative bleeding, and the need for blood transfusion. These inaccuracies occurred because the samples that were included varied based on their standard deviation and pattern-less graph. Conclusion: EuroSCORE II is inadequate to predict morbidity and mortality in postoperative patients, therefore, it is considered less effective.

Background: The impact of COVID-19 may be more severe in developing countries. Our study aims to analyze the accuracy of several inflammatory biomarkers in predicting COVID-19 mortality, providing information about the most suitable markers for developing countries. Methods: A retrospective cohort study was conducted at Dr. Soetomo General Hospital, Indonesia, from March to June 2020. White Blood Cells (WBC) count, Neutrophil-Lymphocyte Ratio (NLR), Procalcitonin (PCT), D-Dimer, and C-Reactive Protein (CRP) have been collected from the electronic medical records. We performed survival analysis to provide the hazard ratio and Receiver Operating Characteristic (ROC) curve analysis to test for accuracy for each parameter. Results: A total of 423 patients who met the criteria for participating had a median age of 54 (IQR 45-61) years. Patients in the death group are characterized by older age and shorter length of hospitalization. The WBC, NLR, PCT, D-Dimer, and CRP are found significantly higher in the death group (P=0.000). The WBC, NLR, PCT, D-Dimer, and CRP have an Area Under the Curve (AUC) of 0.709, 0.773, 0.738, 0.721, and 0.769, respectively moderate accuracy in predicting COVID-19 patient mortality. We found that NLR is significantly more accurate than the age parameter (Z=3.527; P=0.000) but has equal accuracy with other laboratory parameters.  Conclusions: Since NLR obtained the highest accuracy, we still recommend routine complete blood count tests as prognostic biomarkers with the highest feasibility to be performed in developing countries.