Fungal infections such as endemic mycoses, pneumocystosis, candidiasis, aspergillosis, mucormycosis and cryptococcosis associated with COVID-19 are becoming complicated in management and diagnosis of critical ill COVID-19 patients. However, mortality rates due to fungal infections are significantly high. The purpose of this study is to evaluate the effect of fungal infections associated with COVID-19 during the pandemic era. A systemic literature review was carried out to evaluate the effect of fungal infections associated with COVID-19 incidence from relevant published articles.  Invasive Fungal Infections (IFIs) had the highest incidence of 26.7% from 137 intensive care unit patients screened for IFIs in 2020. Currently, drugs that are commonly used in the treatment of COVID-19 patients such as casirivimab and imdevimab, bamlanivimab and etesevimab, sotrovimab, and remdesivir had no any effects on fungal infections. In India, 53% of mortality rate which caused by 60% of Candida auris and in Brazil, 72.7% following corticosteroids use were reported. Recently, no any reports related to mortality rate due to Candida infections associated with COVID-19 in Spain and USA. Numerous current advances in management and diagnosis of these fungal infections associated with COVID-19 have not been much potentially significant. It is predicted and possible that the development of new and potent antifungal drugs, antimicrobial peptides and nanotechnology based approaches for drug delivery would help to reduce or eliminate these fungal infections associated with COVID-19 and restraint its spread across the globe.

This research was conducted to assess the levels of heavy metals in fish tissue, sediment and water body, at river Ndakotsu, Lapai, Niger state, Nigeria. River Ndakotsu is the major river that serve as a boundary between Lapai local government and Agaie local government and is useful to surrounding towns and villages for irrigation farming fishing and domestic purposes. Due to this, it is necessary to monitor the level of heavy metals contamination in the water body, sediment and aquatic species tissue habiting this environment. The study water samples were collected using water sampler in three different locations. Equally, In-situ water physicochemical parameters such as temperature, ph and dissolve oxygen were determined using portable multi probes meter. Fish samples were collected from fishermen immediately they arrived from fish exploration and specimen were digested using concentrated nitric acid in wet digestion technique. The level of selected heavy metal in samples were determined by the use of Atomic Absorption Spectrophotometer (AAS model: Accusys 211 USA) after samples dilution. The water quality of the river was within the acceptable range for fresh water species. The concentration of heavy metals, cadmium (Cd), lead (Pb), copper (Cu), iron (Fe), manganese (Mn) and zinc (Zn). From the results obtained from this study, the concentrations of heavy metals (Mn, Zn, Cd, Cu, Pb and Fe.) found in all the water samples are lower than that in the fish sample species and higher in sediment sample than fish sample