INTRODUCTION: The present study aimed to investigate the mediating role of Islamic work ethic in the relationship between spiritual intelligence and occupational self-efficacy in the Red Crescent relief workers. METHODS: This applied research was conducted based on a descriptive-survey design. The statistical population consisted of all Red Crescent relief workers in Torbat Heydariyeh, Iran (n=146). In total, 106 relief workers were selected using simple random sampling and the required data were collected through standard questionnaires. Finally, the collected data were analyzed in SPSS (version?) and Smart PLS software (version?). FINDINGS: Based on the results, there is a significant positive relationship between spiritual intelligence and occupational self-efficacy of Red Crescent relief workers and the Islamic work ethic is able to mediate this relationship. CONCLUSION: According to the findings, it can be concluded that it is possible to improve the occupational self-efficiency of relief workers through the development and reinforcement of spiritual intelligence and promotion and institutionalization of Islamic work ethic. Therefore, they will be able to play a more effective role in the achievement of organizational goals.