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The trends for health and pro-environmental behaviors led to motivating consumers' attention to use natural skincare products. Purchase intention for natural skincare products can be influenced by several environmental, behavioral, and external factors. In line with global trends, the current study aims to determine the moderated mediation path in the relationship between the aspects of natural packaging of natural skincare products (environmental concerns, packaging design, and printed information), and the intention to purchase natural skincare products purchase intention.A web-based survey was used to gather quantitative data from a convenience sample of 330 participants from Klang Valley, Malaysia. The study outcomes revealed that personal attitude significantly mediated the effect of environmental concerns, natural packaging design, and package printed information on purchase intention. Most importantly, the product safety certificate had a significant moderated mediation effect on the model of environmental concerns, natural packaging design, and purchase intention for natural skincare products. The results contributed to the information and recommendations for stakeholders to consider the packaging factors and safety certificates in the purchase behavior models in promoting the natural skincare products' marketing and industry. Practical ApplicationThe significance of the study lies in the linkage of graphic design to sustainability and marketing management research.

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Xanthorrhizol (XNT), is a bioactive compound found in Curcuma xanthorrhiza Roxb. This study aimed to determine the potential targets of the XNT via computational target fishing method. This compound obeyed Lipinski’s and Veber’s rules where it has a molecular weight (MW) of 218.37 gmol-1, TPSA of 20.23, rotatable bonds (RBN) of 4, hydrogen acceptor and donor ability is 1 respectively. Besides, it also has half-life (HL) values 3.5 h, drug-likeness (DL) value of 0.07, oral bioavailability (OB) of 32.10, and blood–brain barrier permeability (BBB) value of 1.64 indicating its potential as therapeutic drug. Further, 20 potential targets were screened out through PharmMapper and DRAR-CPI servers. Co-expression results derived from GeneMANIA revealed that these targets made connection with a total of 40 genes and have 744 different links. Four genes which were RXRA, RBP4, HSD11B1 and AKR1C1 showed remarkable co-expression and predominantly involved in steroid metabolic process. Furthermore, among these 20 genes, 13 highly expressed genes associated with xenobiotics by cytochrome P450, chemical carcinogenesis and steroid metabolic pathways were identified through gene ontology (GO) and KEGG pathway analysis. In conclusion, XNT is targeting multiple proteins and pathways which may be exploited to shape a network that exerts systematic pharmacological effects.