Up to 3% of people in the world are infected with HCV, and 75-80% of them have chronic currency of infection. In the clinical picture of HCV infection, a significant place is given to extrahepatic manifestations -more than half of patients suffer from lesions of the skin, kidneys, heart, blood vessels, autoimmune and lymphoproliferative syndromes associated with HCV. Usually, mortality from chronic hepatitis C is associated with liver cirrhosis and hepatocellular carcinoma, but in fact, more patients die from complications associated with the development of cryoglobulinemic vasculitis -chronic renal failure and cardiovascular catastrophes. 40-60% of patients with chronic HCV infection suffer from cryoglobulinemic vasculitis in a wide range of clinical manifestations: from minimal to life-threatening. The pathogenesis of mixed cryoglobulinemia syndrome is based on polyclonal activation of lymphocytes.The systemic nature of the lesion, which is observed in HCV infection, reflects its generalized nature with the involvement of many organs and tissues in the pathological process, which complicates timely diagnosis and treatment. A variety of systemic extrahepatic pathology, which often outstrips the clinical picture of hepatitis itself, masquerading as another disease means that a specialist of any profile can meet with chronic HCV infection and its consequences.

SARS-CoV-2 caused by beta-coronavirus RNA spread from the Chinese city of Wuhan in December 2019 and it had been a global pandemic. Today, more than sixty-six million cases of infection are registered in the world, moreover above one and half million people die. For today's situation, 137 000 individuals are infected and approximately 2 000 people die in Kazakhstan.To investigate the independent risk factors associated with Coronavirus-2 Severe Acute Respiratory Syndrome and mortality rate in Almaty (Kazakhstan).А retrospective study was provided according to the participants' medical records with the COV-ID-19 and who were in the hospital in the period from June till August of 2020 in city hospital of Almaty, Kazakhstan. Among all 278 patients which were included to our issue 76 of them were unsurvived, and the rest were survived.The survey has been conducted in a retrospective design of the medical records of those people with COVID-19 and patients who have been registered in Almaty city hospital, Kazakhstan in the period of June to August of 2020. Among all 278 participants who attached to our release, 76 of them were dead.The correlation indirectly out of the seriousness of hepatocytes' cytolysis and the development in deceased patients severe type lymphopenia cause of the liver damage is a direct cytopathic effect on hepatocytes SARSCov2, since an absolute decrease in lymphocytes caused by virus-induced apoptosis correlated with the severity of viral load and is a significant and independent predictor of death.