The main goal of this study is to identify the factors that influence the profitability of commercial banks in Malaysia by examining recent data from 2010 to 2020. To achieve this objective, the study uses Return on Assets (ROA) as a measure to assess the relationship between capital adequacy, credit risk, management efficiency, and liquidity risk. The research collects data on ROA, capital adequacy, credit risk, management efficiency, and liquidity risk from Bursa Malaysia and company websites. Additionally, secondary data sources are utilized to gather information and provide evidence for the analysis. The aim of the investigation is to assess whether the determinants of commercial bank profitability in Malaysia are capital adequacy, credit risk, management efficiency, and liquidity risk. Multiple Linear Regression is employed to examine the factual relationship and evaluate the hypotheses, and the software used to analyze the results is E-views 2012.