Background: This study aimed to investigate the association of rs1695 polymorphism in glutathione S-transferase P1 (GSTP1) with risk of oral cancer in a meta-analysis which was followed by a bioinformatics approach. Materials and methods: Related articles were collected through a systematic search in PubMed, Google Scholar, and EMBASE databases up to June 2022 and then screened. Finally, seven studies, including 1249 cases of oral cancer and 1861 healthy individuals, were included in our meta-analysis. Seven different genetic models including G vs. A, GG+GA vs. AA, GG vs. GA+AA, GA vs. GG+AA, GG vs. GA, GG vs. AA, and GA vs. AA were used for the calculation of odds ratio and 95% confidence interval in order to assess the association between GSTP1-rs1695 polymorphism and oral cancer risk. Also, the ethnicity-based stratified analyses were performed using the seven mentioned models. Some bioinformatics software was used to investigate the effect of rs1695 polymorphism on the primary, secondary, and three-dimensional structure of GSTP1. Results: Our results showed that rs1695 polymorphism was not associated with the risk of oral cancer in any seven genetic models (G vs.

Cartilage injuries and osteoarthritis are among the most common problems of the elderly in the world, and common treatments are limited to relieving pain. Today, tissue‐engineering is one of the most important hopes of finding a cure to overcome these problems. Therefore, the present study aimed to examine the potential impact of Ursolic acid (UA) blended with electrospun nanofibrous scaffolds fabricated by polycaprolactone (PCL) and poly(L‐lactic acid) (PLLA) on the chondrogenesis capacity of the mesenchymal stem cells (MSCs). Characterization results of the scaffolds revealed that the hydrophilicity and biocompatibility of the PCL‐PLLA nanofibers increased significantly and therefore MSCs attachment and proliferation improved in comparison with empty nanofibers. In addition, differentiation evaluation was also indicated that the expression level of chondrogenic‐related genes was increased significantly in MSCs differentiated on the PCL‐PLLA‐UA nanofibers compared to the differentiated cells on the PCL‐PLLA nanofibers. Alcian blue staining was also revealed that glycosaminoglycans production was amplified significantly in the cells differentiated on the PCL‐PLLA‐UA nanofibers. Fibronectin protein expression that is an important pre‐cartilage condensation marker was also increased in MSCs differentiated on the UA containing scaffold. In summary, the results indicated a significant improvement in the chondrogenic differentiation potential of the MSCs when differentiated on the PCL‐PLLA‐UA nanofibers. It can be concluded that this cell‐scaffold combination can be suggested as potential candidate for cartilage tissue‐engineering applications.