Introduction: Exercise has an important impact of health and is an inseparable way to managing diabetes mellitus. The purpose of this study is to examine impact of the period of high-Intensity interval training and at the same time strength-endurance training on the levels of some adipokines associated with insulin resistance in diabetic women. Materials and Methods: Fifty-two overweight female type 2 diabetic patients (45-60 years old with fasting blood glucose ≥ 126 mg/dl (7.0 mmol/l)) were assessed and based on glycosylated, Hb were assigned into the intense interval training group (N = 17), concurrent resistance-endurance training group (N = 17) and control group (N = 18). Strong-endurance group subjects did three sessions of endurance training with 60% maximum heart rate (MHR) and two sessions per week of resistance training with 70% repeat maximum (1-RM). Intensity interval training group did three sessions of 4 to 10 repetitions of a 30-minute Wingate test on the ergometer with maximum effort for eight weeks. The control group did not have any regular sports activities. At the end of experiment, 42 subjects completed the study and 10 subjects were excluded. Fasting blood glucose and insulin levels were measured 24 hours before and 48 hours after the last exercise session. Data were analyzed by t-test and covariance analysis. Results:The results showed that, levels of apelin in HIT and combine training group have no significant changes (P = 0.13 and P = 0.09, respectively), but visfatin in HIT Group (P = 0.003) and combine training group (P = 0.001) has significant changes. Also changes in IL-6 in intense interval training (P = 0.09) or combined training groups (P = 0.07) was not significant. Likewise TNF-α has no changes in extreme speed (P = 0.11) and combined (P = 0.23). But we observed significant differences in the levels of MCP-1 in high-intensity exercises in group training and concurrent training groups (P = 0.001, P = 0.045, respectively). Conclusions: HIT accompany with strength-endurance training can have positive effects on the levels of glucose, insulin, insulin resistance, MCP-1 and visfatin in women with diabetes mellitus.