This research was conducted to determine the prevalence and pathological lesion of Trichomonas gallinae in pigeons in the northeast part of Iran. Wet mount preparations from the oral cavity/crop of 418 pigeons (Columba livia) captured from various locations in Khorasan province analyzed for T. gallinae by Giemsa's staining between April 2008 and June 2009. A total of 418 pigeons, 37.32% (n = 156) were infected with T. gallinae. Macroscopically, the oropharynx of infected pigeons has white, caseous lesions or stomatitis. Microscopically, there was moderate congestion with infiltration of mononuclear inflammatory cells in the lamina propria of pharynx, hyperplasia of mucous cells in epithelia of trachea with infiltration of mononuclear inflammatory cells, numerous granulomatous foci in the livers with many multinucleated giant cells, tubulointerstitial nephritis with multifocal to diffuse infiltration of mostly mononuclear inflammatory cells in the kidneys. In the present paper we have described for the first time the co-existence of both genotypes of T. gallinae based on pathological lesions in this area.

BackgroundRecently the role of gastrointestinal nematodes in modulating the immune responses in inflammatory and immune-mediated conditions such as allergy and autoimmune diseases has been introduced. This is mainly due to the suppressive effects of somatic and excretory secretory (ES) products of nematodes on the immune responses. In this study, we evaluated the immunomodulatory potentials of somatic products of Marshallagia marshalli, a gastrointestinal nematodes of sheep, to suppress the immune-mediated responses in a murine model of allergic airway inflammation. BALB/c mice were intraperitoneally (IP) sensitized with ovalbumin (OVA)/Alum and then challenged with 1% OVA. Somatic products of M. marshalli were administered during each sensitization. The effects of somatic products on development of allergic airway inflammation were evaluated by analyzing inflammatory cells recruitment, histopathological changes, cytokines production (IL-4, IL-13, IL-10, TGF-β) and serum antibody titers (IgG1, IgG2a).ResultsSomatic products of M. marshalli were able to suppress the induction of allergic airway inflammation in mice. Modulation of Th2 type responses (IL-4, IL-13, IgG1) via upregulations of IL-10 and TGF-β production was observed after injection of somatic products of M. marshalli. In addition, inflammatory cells infiltration and pathological disorders were significantly diminished following administration of somatic products.ConclusionsOur data raised the possibility that helminths could be a potential therapeutic candidate to alleviate the inflammatory conditions in allergic asthma. According to these results, we concluded that M. marshalli may contain immune-modulatory molecules that attenuate allergic airway inflammation via induction of regulatory cytokines. Further investigations are required to identify molecules that might have potentials for development of novel therapeutic targets.

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After publication of this article it was brought to our attention that we omitted to acknowledge overlap of some text with the article by Sansano-Maestre et al. (2009). We apologise to Sansano-Maestre et al. and to readers for this omission.