Temporary traffic control (TTC) strategies have been widely adopted to maintain traffic flow while ensuring TTC costs remain a reasonable portion of construction budgets. As travel demand approaches the capacity of an existing facility, implementation of an appropriate TTC strategy is increasingly important not only because lane closures on these facilities exacerbate existing delay, but also because speeds associated with congestion contribute disproportionately and non-linearly to roadway emissions produced throughout the lifetime of the roadway. To enable stakeholders to make informed and transparent decisions on selecting a TTC strategy so as to balance the trade-offs among construction cost, traffic delay, and energy consumption, this paper discusses the development of an integrated model that identifies the Pareto-optimal front when construction start time, construction duration, lateral clearance, and width of shoulder borrowed as a through lane are considered as decision variables. A test implementation of the model suggests that when construction budgets are low, strategies for decreasing traffic delay differ significantly from those for decreasing energy consumption; however, as construction budgets increase, the objectives on traffic delay and energy consumption align much better.
The immuno-regulatory cytokine interleukin 10 (IL-10) is important in reducing the inflammatory response during H. pylori infection. The goal of our study was to explain how H.pylori infection affects mucosal IL-10 mRNA expression. This study included seventy-three patients suffering from gastroduodenal disorders admitted to Assiut University Hospitals, (35 (47.95%) were males, and 38 (52.05%) were females). Three antral biopsies were obtained from each patient during endoscopic examination. Two invasive tests (Rapid urease test (RUT) and polymerase chain reaction (PCR)) were performed for the detection of H. pylori infection in all participants. Real time PCR (RT-PCR) was performed for determination of IL-10 mRNA expression. Results of RUT and PCR indicated that 60.27% of patients were H. pylori infected. Our results showed that patients positive for H. pylori had significantly higher IL10 mRNA expression than H. pylori-negative patients. Finally, overexpression of IL-10 during H. Pylori infection may be implicated in the downregulation of excessive immune response.
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