Many techniques, approaches and tools were used in this Research to achieve the Methodology. Using artificial neural network to simultaneous hydraulic parameters is one of these techniques. Transmissivity and storativity consider the most important parameter in each aquifer due to the reality of their effect on the aquifer properties. In this research, it is assumed that the transmissivity (T) and the storativity (S), represented by coordinates (X), (Y), hydraulic head (H), and observation times (t). These variables were chosen depending on the literature review. In the present study, the hydraulic head values at each cell (H) and the location of the cells (x, y) are considered as input parameters for finding the unknown parameters. The transmissivity (T) and storativity values (S) at cells are assumed and used in the finite difference method (Forward model) in order to find the value of hydraulic head at that cell. The hydraulic head values were used in the artificial neural networks (Inverse model) to estimate transmissivity (T) and storativity values (S) for Wadi El Natrun Depression. The study is based on coupling of forward model and inverse model. In general, the parameter estimation process consists of identifying a model that would reverse a complex forward relation.