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Background: The current Covid-19 pandemic massively overwhelmed the health scene in almost all world countries including Egypt. Neurological manifestations are commonly reported among Covid-19 patients. Aim of work: to describe the neurological manifestations in a group of Egyptian patients diagnosed with Covid-19. Patients and Methods: The present retrospective study was conducted at Al-Azhar University Hospitals. Patients included in the study comprised 50 patients with variable new-onset neurological manifestations in addition to other 50 patients without neurological manifestations recruited from other departments. All participants were subjected to careful history taking, thorough clinical examination and routine laboratory investigations. Patients with neurological manifestations were in addition submitted to computed tomography (CT) or magnetic resonance imaging (MRI) as appropriate. The primary outcome of the present study is patients' in-hospital mortality. Results: Comparison between both groups shows that patients with neurological affection are significantly older (54.7 ± 12.8 versus 44.2 ± 18.8 years, p=0.002) with significantly higher BMI (32.4 ± 7.8 versus 26.3 ± 6.5 kg/m^2, p<0.001). The reported neurological manifestations included headache (78.0 %) taste and smell impairment (74.0 %), myalgia (62.0 %) and dizziness (58.0 %). It was also shown that 30 patients (60.0 %) died among patients with neurological affection while in patients without neurological affection only 13 patients (26.0 %) died (p=0.001). Neurological manifestations are independent predictor of mortality [OR (95% CI): 0.35 (0.14-0.88), p=0.025]. Conclusion: Neurological manifestations are common in Covid-19 patients. There is a significant association between the presence of neurological manifestations and mortality.

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Background:The second prevalent cause of death globally is cerebrovascular stroke. It's responsible for a great extent of disabilities than any other condition. A large share of this disability is related to poststroke neurocognitive impairment. Aim of the study: This study aimed to assess neuroimaging indices related to cognitive dysfunction in a sample of Egyptian stroke patients. Patients and Methods: This study included 70 patients diagnosed with ischemic or hemorrhagic stroke after 3 months from the onset. Cognitive functions were assessed using the Montreal Cognitive Assessment test (MoCA). Results: This study included 70 stroke patients. They comprised 29 men and 41 women with an age of 52.9 ± 10.4 years. According to MoCA score, cognitive impairment was detected in 22 patients (31.4 %) while the remainder 48 patients had normal cognitive function. Patients with cognitive impairment are significantly older (59.6 ± 6.2 versus 4 9.9 ± 10.6 years; p<0.001) and have significantly higher frequency of atherosclerotic disease (64 % versus 36 %, p<0.001). It was found that patients with cognitive impairment show significantly higher frequency of left hemisphere strokes (68 % versus 42 %; p=0.039), both cortical and deep strokes (59 % versus 18 % and 23 %; p=0.042). It was also demonstrated that patients with cognitive impairment had significantly larger stroke lesions when compared with patients with normal cognition (12.8 ± 1.9 versus 3.9 ± 0.9 cm; p<0.001). Conclusion:Cognitive impairment is prevalent in stroke patients. Risk factors included older age, left hemispheres strokes, cortical strokes and larger stroke lesions.