Background: Cerebral palsy is the most common cause of motor disability in children. Parents of children with cerebral palsy experience more stress than parents of typically developed children. The aim of the current study is to find out the relation of parent stress between activities of daily living and gross motor limitation in children with diplegic cerebral palsy; and investigate the relation between parent stress and their quality of life. Patients and Methods: A cross sectional study of 107 children with diplegic cerebral palsy, aged from 2-4.8 years, assigned to two groups; Group A included ambulant children on level I, II and III on gross motor function classification system, while Group B included non-ambulant children on level IV and V. Parent stress and quality of life was assessed by parenting stress index -short form and pediatric quality of life inventory family impact module respectively, while activities of daily living and gross motor impairment were assessed by Wee functional independency measure and gross motor functional classification system respectively. Result: There was a positive correlation between parent stress and gross motor limitation in Groups A and B (r= 0.865 and 0.489, respectively). In addition, there was a positive correlation between parent stress and quality of life in Groups A and B (r= 0.982 and 0.785, respectively). Negative correlation between parent stress and activities of daily living (required total score) in Groups A and B (r= -0.911 and -0.811, respectively) also was found. Conclusion: Activities of daily living and gross motor limitation may have an effect on parent stress.