Tamarind (Tamarindus indica) belongs to the family Leguminosae. It is commonly growing in tropical and subtropical regions now and is one of the most important plant resources as cuisine materials. Antioxidative activity of tamarind seeds was investigated. An ethanol extract prepared from the seed coat contained antioxidative activity as measured by the thiocyanate and thiobarbituric acid (TBA) method. Essential oils are highly odorous droplets found in minimal quantities in the flowers, stems, leaves, roots and barks of aromatic plants. They are not recognized as true oils as the vegetable oils, but highly fluid and volatile. Experts recognize an essential oil by its aroma and test the oil characteristics such as vaporization and crystallization point using Differential Scanning Calorimetry (DSC). DSC has emerged as a powerful experimental technique for determining thermodynamic properties of biomacromolecules. Volatile components of tamarind leaves and seed locally grown will be isolated by Microwave Assisted Extraction (MAE). The presence of essential oil as the volatile components will be investigated to determine whether this method is effective or not to extract the oil from tamarind leaves and seed. The parameters that will be measured are the time for the oil droplets formation and the optimum temperature for the extraction of oil. At the end of the extraction, amber color oil was obtained. Results showed that the time for the oil droplets formation increasing with the increasing weight of sample for both tamarind leaves and seed samples. The optimum temperature for the extraction obtained was 125ºC with the yield of 1.2 mL of seed oil. The vaporization and crystallization point of oil are presented in the DSC curve and the specific heat capacity of the oil are calculated.