The aim of this investigation was to assess the influence of peanut (Arachis hypogaea) skin extracts on pancreatic protective and therapeutic effects and reduce the level of blood glucose on laboratory animals damaged by Carbon Tetrachloride (CCl4). The study began with the collection of seed coats, maceration and Soxhelt apparatus were used to prepare aqueous and methanolic extracts respectively, phytochemical detection, and acute toxicity of peanut skin extracts and antidiabetic testing of male mice with the carbon tetrachloride (CCl4). Forty male albino mice were randomly divided into ten groups of four animals each. The experiment was conducted in two methods: pre-treatment groups and post-treatment groups. The results showed that the serum blood glucose level was significantly increased (p <0.01) in the CCl4 treated group (group 2) of mice (172.00 ± 2.08 mg/dl) compared with the control group (group 1) (101.43 ± 2.02 mg/dl) indicating the induction of severe pancreatic toxicity. The best effect in the level of serum blood glucose was in methanolic treated groups 100 mg/kg (Group 4 and 8) (104.27 ± 2.07 and 107.10 ± 1.75 mg/dl) respectively in both pre and posttreatment when compared with the control group. The histopathological examination of pancreas obtained from mice with administrated CCl4 showed fatty changes in the cells of islet and depletion of secretion, while when treated with 100 mg/kg of methanolic extract revealed the islets of pancreas look like normal structure appearance.