Oral health-related quality of life (OHRQoL) is an essential indicator of people’s overall health and health-related quality of life. Poor oral health and OHRQoL among young adults lead to numerous negative consequences and an increased burden on the healthcare system. The present study is aimed at assessing the OHRQoL among the young adults of Saudi Arabia, identifying self-rated oral health, and determining the relationship between sociodemographic and lifestyle factors with the OHRQoL. The present analytical cross-sectional survey was conducted among 1152 health and non-health-related college university students from three randomly selected universities. The OHRQoL was evaluated using the validated Arabic version of the oral health impact profile-14 questionnaire (OHIP-14). Of the population studied, one-fourth of the participants (24.9%) reported poor or fair oral health, and the highest OHIP-14 score was found in the domains of physical pain (4.14), followed by psychological discomfort (4.07). Logistic regression analysis revealed that the poor oral health category was significantly associated with male gender (ref: female: adjusted OR AOR = 1.89 , 95 % CI = 1.23 – 2.94 , p = 0.004 ), daily smokers (ref: nonsmokers: AOR = 3.47 , 95 % CI = 1.97 – 4.82 , p < 0.001 ), chocolate and candies intake more than once a day (ref: never; AOR = 1.54 , 95 % CI = 1.10 – 2.19 , p = 0.034 ), and did not seek periodical dental care (ref: periodic dental care received: AOR = 2.23 , 95 % CI = 1.53 ‐ 2.86 , p = 0.002 ). The present study revealed the factors associated with poor OHRQoL. The concerned authorities should consider the implementation of periodic dental checkups for university students, especially for the high-risk group. Furthermore, it is recommended to have regular health education programs that will help to change the student’s lifestyle and poor oral health behaviors.