Women participation in economic development has been identified to be of importance, most especially in the area of entrepreneurship. However, women the world over play a substantial role in the socio-economic and political development of any country. Given this, the current study examined the effect of socio-cultural factors on women entrepreneurship development in Kaduna state. The specific objectives of the study include: to examine the effect of religion on women entrepreneurship development in Kaduna State; to examine the effect of culture on women entrepreneurship development in Kaduna State; and to examine the effect of gender roles on women entrepreneurship development in Kaduna State. Using descriptive survey research design, data were collected from 332 women entrepreneurs in Kaduna metropolis and then analyzed via correlation and regression analyses techniques to examine the cause, effect, strength and degree of the relationship between socio-cultural factors and women entrepreneurship development. The study found that there is a significant relationship between socio-cultural factors and women entrepreneurship development in Kaduna metropolis, indicating significant relationships between religion and women entrepreneurship, between culture and women entrepreneurship and between gender role and women entrepreneurship development in Kaduna metropolis. The study recommends that women entrepreneurs in Kaduna metropolis should be proactive in doing business by bearing in mind various socio-cultural factors such as religion, culture and gender roles that may hinder the smooth running of their businesses.