Heavy metal levels (Copper, zinc, lead, and cadmium) in water and fish (Nile tilapia) have been evaluated in three different locations in (EL-Kapoty) Lake Manzala. Metals' quantities in both fish tissues and water were measured. Fish samples with weights ranging between 78.7 and 42.3gm varied significantly by area and season. All metals under study peaked in summer and dropped in winter. The levels of different metals in fish tissues and water were ordered in the correct sequence: Copper > zinc > Lead > cadmium. In water, the mean concentrations of metals were as follows: Cd is 0.006 mg/L, Pb is 0.007mg/L, Zn is 0.032mg/L, and Cu is 0.007mg/L. The water's cadmium amount was higher than the limit allowed for drinking water. The mineral concentration in fish organs was much higher than in water. The gills of the tested fish had the greatest mineral concentration, while the muscles showed the lowest. Despite the fact that Lake Manzala was polluted with heavy metals, the amount of minerals in the fish's muscles did not overpass the limits allowed, making the fish safe. Elements. Site.Seasons. ANOVA.Winter Spring Summer Autumn Mean.Factor. F-value. Sig.