Introduction:Inguinal hernia is the most commonly hernia in both men and women but occurs more common in men. Although there are two basic types of inguinal hernia with differences in anatomy, the etiology, complications, and surgical repair technique of both are very similar. The aim of this study was to evaluate the demographic and clinical characteristics of patients with inguinal hernia who underwent either elective or emergency surgical hernia repair at Al-Basra Teaching Hospital. Methods: This was a prospective clinical study involving patients with inguinal hernia admitted to Al-Basra Teaching Hospital from February 2017to November 2019. Patient's demographic data, smoking habit, body mass index, history of chronic diseases, family history of inguinal hernia, and post-operative complications were evaluated. The patients were divided into seven groups according to age. All data were recorded and analyzed. Results: A total of 250 patients age 16 to 82 years were included (men, 88.4%, women, 11.6%) in this study. Most of the patients were above the age of 40, nearly half of the patients were smokers and had a positive family history of inguinal hernia. Most patients had normal body weight, and 12% of patients developed postoperative complications. Conclusion: We concluded that a large proportion of patients with inguinal hernia were men and they underwent elective hernia repair. All of patients with recurrent hernia were found to be smokers. Patient who underwent elective hernia repair had minimal postoperative complications with short hospitalization.

The present study aimed to evaluate some of side effects of methotrexate adminstration (MTX) in the treatment of complete Freund's adjuvant (CFA) induced arthritis. Thirty Wistar male rats weighing 180-200 g were divided in 3 groups and arthritis was induced in them by using Complete Freund's Adjuvant, except in group I. In group II after the induction of arthritis no treatment was given. Group III received methotrexate as an anti-inflammatory medicine. After RA induction, all the animals received CFA near the site of tibio-tarsal joint subcutaneously. The clinical features of the adjuvant induced arthritis like difficulty in movement and edema in joint appeared 3 days after inoculation of adjuvant. The onset of inflammation was explosive occurring 13-15 days post inoculation with a peak onset at day15. The rats in group III received treatment with MTX subcutaneously from day 15 to day 30. At the end of experiment, blood collection was done for liver, kidney functions and heamatological observations. The present study demonstrated significant elevation in liver functions (ALT and AST) compared with normal control rats on the other hand there was increase in kidney functions but not significant. In contrast there was depletion in RBCs cont and Hb level.

The complete blood picture or count (CBC) and different hematological measurments are widely used in the assessment of many health problems such as cancer prognosis and progression. The roots of Chinese herb Tripterygium wilfordii (TW) is well-defined in Chinese alternative medicine since it is rich in a lot of beneficial components such as terpenoids, alkaloids and steroids. The intratumoral treatment with TW ethanolic and aqueous extracts individually and mix of them at a dose (16 mg/ kg) in Ehrlich ascites carcinoma (EAC) bearing mice had ameliorated the different hematological parameters such as red blood cell count (RBCs), hemoglobin concentration, white blood cells (WBCs) count and differential, as well as platelet count near normal values. Treatment with cisplatin (2mg/kg) revealed many undesired hematological side effects like anemia, leukopenia and neutrophilia. Moreover, recently used inflamatory markers as prospective diagnostic parameters for cancer prognosis like monocyte lyphocyte ratio (MLR), neutrophil lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) were decreased significantly after treatment with TW extracts. In conclusion, treatment of EAC bearing mice with different extracts of TW could have anticancer activity regarding their remarked effect in improvement of distorted hematological parameters of the EAC bearing mice.

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Introduction: Peptic ulcer perforation is the most common complication in peptic ulcer disease and can lead to serious complications and mortality; however, despite the widespread use of antisecretory agents and eradication of Helicobacter pylori, the incidence of peptic ulcer perforation remains largely unchanged. This study aimed to evaluate the risk factors for perioperative morbidity and mortality in patients with peptic ulcer perforation. Methods: This was a prospective, observational study involving patients with perforated peptic ulcer disease admitted to the Al-Basra Teaching Hospital from January 2017 to December 2019. A total of 100 patients were followed for 4 weeks. Patients’ demographic data, history of chronic diseases, American Society of Anesthesiologist (ASA) score, nonsteroidal anti-inflammatory drug (NSAID) and steroid use, duration before surgery, preoperative shock status, previous symptoms of peptic ulcer disease, smoking habits, and fasting status were evaluated, and significant correlations with postoperative complications were analyzed statistically. Results: A total of 100 patients aged 16–87 years were included in the study, and the male-to- female ratio was 3:1. Sixty-seven (67%) patients underwent surgery within 12 h after admission, 41% of patients had a history of chronic disease, 54% of patients had an ASA score of 1, 57% of patients were smokers, 45% of patients reported previous peptic ulcer symptoms, and 22% of patients had preoperative shock status. Thirty-seven (37%) patients developed postoperative complications, and 8% of patients died. Conclusion: This study confirmed that advanced age, a high ASA score, preoperative shock, comorbidities, and delayed presentation before surgery were all risk factors for postoperative complications and mortality in patients with perforated peptic ulcer disease. Habitual smoking, fasting status, and NSAID and steroid use were not correlated with mortality.