Background: The primary outcome was to evaluate whether goal-directed fluid therapy (GDFT) protocol, established on stroke volume variation (SVV) and oxygen delivery index (DO 2 I) using electrical cardiometry (EC) monitor, would be effective in reducing perioperative packed red blood cells (RBCs) transfusion, whereas the secondary outcome was to compare the effects of GDFT with liberal fluid therapy (LFT) as regards total amount of fluids transfused, perioperative complications, and postoperative length of ICU and total hospital stay. Settings and Design: This study was a prospective randomized controlled clinical trial. Methods: The study was carried out on 48 patients scheduled for scoliosis surgery. Twentyfour patients, whose intraoperative fluid administration was managed with the GDFT protocol, were compared with 24 patients who received a liberal intraoperative fluid therapy.The proposal and raw data were registered on PACTR as PACTR202007901764021. Results: Patients in group II received less units of packed RBCs (P < 0.001) and a lower volume of intraoperative crystalloids (P < 0.001). They had significantly lower serum lactate levels 2 h after induction (P = 0.033), at the end of surgery (P = 0.001) and 2 h postoperatively (P < 0.001) with shorter ICU stay (P < 0.001), total hospital length of stay (P < 0.001), and faster return of bowel function (P = 0.005). Conclusion:: Application of a GDFT protocol, established o SVV and DO 2 I using EC monitor in patients undergoing scoliosis surgery, can lead to reduced packed RBCs transfusions, reduced total crystalloid volume infusions, less postoperative pulmonary complications, shorter ICU, and total hospital stay with faster return of gastrointestinal function.