Additional uterotonics were needed less frequently by patients treated with carbetocin. Carbetocin was comparable to oxytocin and superior to misoprostol in the prevention of uterine atony following an elective cesarean delivery. ClinicalTrials.gov: NCT02053922.

Endometrial injury using a Pipelle catheter in the stimulation cycle may improve pregnancy rates in women undergoing intrauterine insemination.

Background Although many trials have been made to augment the unilateral alar base depression, the ultimate aesthetic satisfaction has proven difficult to achieve. In our study, we present a novel submucosal dissection technique to harvest the vomer bone and use it as an onlay graft to correct the alar base depression. Methods We collected a prospective cohort study of 11 patients with unilateral cleft lip nasal deformity. Using CorelDRAW X7 software, we obtained perioperative clinical photographs to analyze the nostril and lateral lip morphometric measurements on the cleft side. Computed tomography scans were used to assess the required graft's volume and to detect resorption. We performed vomerine ostectomy and placed and fixed the bone graft in with a lag screw over the alar base depression. Results The nostril width showed a significant increase, in addition to the height/width ratio. The columellar angle with the lateral lip height increased remarkably, with a general improvement in the nasal tip aesthetics. Conclusions The vomer bone graft has been shown to correct the lateral and inferior disorientation of the alar base and improve the nostril and nasal tip aesthetic measurements. The vomer bone is therefore a sufficient bone source for grafting with high viability and no resorption.

The internal nasal valve provides most of the upper airway resistance; therefore, many surgical techniques have been developed to reconstruct and widen this sensitive area of the nasal airway. Twenty patients participated in this study to compare the effects of 2 techniques (spreader grafts and modified spreader flap) on the true valve area and the average valve area after rhinoplasty according to standard axial computed tomography on admission and 6 months following the surgery. The mean follow-up time was 10.2 months. After rhinoplasty, the average valve area increased in all patients who underwent the spreader graft or modified spreader flap techniques. The preoperative average valve areas for patients undergoing the spreader graft and spreader flap techniques were (37.10 ± 16.45 mm2) and (36.86 ± 10.56 mm2), respectively, whereas the postoperative results were (48.58 ± 12.85 mm2) for those who underwent the spreader graft technique and (56.22 ± 19.06 mm2) for those who underwent the modified spreader flap technique. Both techniques resulted in significant radiological and clinical improvement with a good correlation between the subjective and objective tests. Level of Evidence IV.

Background: T1DM is considered as the most common chronic metabolic autoimmune disorder in childhood and adolescence as well as in the early adulthood. It appears frequently during 12- 13 years of age with distinctive features like immune-mediated chronic damage of pancreatic β-cells, leading eventually to partial, or mostly, absolute insulin deficiency. Insulin-like growth factor 1 (IGF-1) is a polypeptide consisting of 70 amino acids with insulin-like chemical structure. In most cases, IGF-1 is a reliable growth marker and an anabolic one in adults. It plays an important role in the regulation of various physiological functions, e.g., glucose metabolism, cell survival and proliferation. Objective: To compare the levels of IGF-1 in children having type-1 diabetes with that of healthy controls and also to determine whether there is a relationship between IGF-1 and physical features in T1DM. Patients and Methods: The current study was conducted on 85 children of both sexes. Seventy patients were less than 12 years old with T1DMselected according to ADA 2014 criteria for diagnosis of diabetes from pediatric diabetes clinic at Ain Shams University hospital. All patients were divided into 2 groups based on the duration of diabetes to T1DM>1year duration and T1DM < 1year duration and they were compared with fifteen normal children, attending the pediatric general clinics as a control group. Measurements of height, weight, and arm span, upper body segment, lower body segment, and body mass index, parents’ height beside Fasting blood glucose, HbA1C, IGF-1, FSH, and LH were noted. Results: Height percentile significantly higher inT1DM less than 1 year median 50 (10 to 75) than T1DM more than one year (median10 (3 to 44) p-value 0.007). IGF-1 level in the group of T1DM less than 1year median 90 (70 to 110) (ng/ml) was significantly lower than other groups (p-value 0.0008). IGF1 has a significant positive relation with Aram span in group T1DM more than 1year (p-value 0.024), positive significant relationship between mother height and IGF-1 level in group T1DM less than 1 year (p-value 0.013). Conclusion: IGF-1 level is reduced by the recent onset of T1DM but still it has some effect on the somatic features even in the presence of longstanding diabetes.