Background: In the current COVID-19 pandemic, which is caused by severe acute respiratory syndromecoronavirus-2 (SARS-CoV2), disease diagnosis is essential for optimal management, timely isolation of infected cases in order to prevent further spread and is associated with significant morbidity and mortality burden.Objective: To assess the liver impairment as a predictive factor for mortality rate of COVID -19 patients. Patients and Methods:The prospective study included 100 patients with Covid-19 infection who were admitted to Al-Hussein and Bab Al-Sha‫׳‬aria University Hospitals. The study was during the period from 1st of February 2021 to 31th of May 2021 and divided in to five groups according to liver functions tests. Presenting clinical manifestations, laboratory findings, radiological findings and mortality rate were recorded from electronic medical records. Diagnoses of COVID-19 patient were done according to criteria of ministry of health and population-Egypt. Results:The results revealed that the mean of platelets reaching to a minimum mean value at group E and the mean of the neutrophil /lymphocyte ratio reaching to a maximum mean value at Group E, while the lymphocyte /monocyte ratio reaching to a minimum mean value at Group E. There were significant difference among all groups regarding ALT, AST, total bilirubin, direct bilirubin and serum Albumin with P value =0.001 in all parameters. Also there were significant decreases of serum albumin in groups C, D and E when compared with group A, and there were significant increases of total bilirubin, direct bilirubin mean values in group E when compared with group A. There were significant increase of prothrombin time (PT) and INR in groups E when compared with group A. The results showed a significant difference (p-value <0.05) between recovered and died cases for each group with higher mortality rate at group D (7 cases with a percent of 30.4%), then at group E (3 cases with a percent of 25%), and there were 88% recovered and 12% died in all studied COVID-19 patients. The results revealed that the higher mortality rates at group D and E between patients having chest CT scoring 4 and 5. Conclusion:Patients with accompanying chronic liver diseases are predisposed to developing a more severe course of COVID-19 and increase the mortality rate, but on the other hand, a more complicated presentation of SARS-CoV-2 infection increases the risk of liver failure.

Background. Surgical resection with clear surgical cut margins is the mainstay of managing malignant breast neoplasms. Multiple techniques have been suggested to enhance resection status during breast-conserving surgery (BCS), including intraoperative ultrasonography (IOUS). Herein, we conducted the current investigation to reveal the benefit of IOUS on the achievement of R0 resection. Patients and Methods. This retrospective investigation included 140 patients who underwent BCS. They were divided into two groups: the IOUS group (40 cases) and the control group (100 cases). Our primary objective was to determine the free resection margin status (R0). Results. Both study groups expressed statistically comparable demographic and clinical data. Additionally, histopathological examination revealed no significant difference between the two groups regarding the tumor type, stage, or grade. Nonetheless, the R0 resection margin was more frequently encountered in association with IOUS application (97.5% compared to 79% in the control group), and that difference was statistically significant ( p = 0.007 ). Conclusion. The application of IOUS has a significant beneficial impact on the outcomes of BCS. It is associated with a marked decline in positive resection margins, and its application should be encouraged in the breast oncological practice.