To evaluate factors associated with restenosis after angioplasty of popliteal artery lesions in patients presenting with chronic limb threatening ischemia. Methods: A prospective non-randomized study between from August 2018 to December 2020 conducted on 25 patients presenting with chronic limb threatening ischemia and having popliteal artery atherosclerotic occlusive disease (median age 65.52 (±8.35) years). Plain balloon angioplasty was done and patients were followed for 6 months. The primary outcomes were the primary patency and predictors of restenosis. Results: The primary patency at 6 months was 64%. Restenosis after angioplasty was associated with the presence of multilevel disease (p=0.036), presence of complete total occlusion (p=0.003), and subintimal angioplasty (p=0.005). Other studied variables weren't associated with patency loss. Conclusion: Angioplasty of popliteal atherosclerotic disease is feasible and has accepted short term primary patency rate. The presence of multilevel disease, popliteal complete occlusion, and the use of subintimal angioplasty were associated with lower primary patency after 6 months.