IntroductionPatients that are complaining from tinnitus but have normal hearing comprise an uncommon group and there is rare literature about them. Deficiency in B-complex vitamins has been shown to result in tinnitus and supplementation may improve the symptom which means manipulation of cochlear status. Distortion Product Otoacoustic emissions (DPOAEs) used frequently to assess cochlear status.ObjectivesThe uses of DPOAE changing amplitude as a parameter to estimate effect of vitamin B complex on changing the severity of tinnitus in patients with tinnitus only in comparison to patients have tinnitus with Sensory Neural Hearing Loss (SNHL) and a control group.MethodsProspective observational cohort study was performed in AL-Karama Teaching Hospital as a secondary medical care center, from 01/01/2012 to 31/12/2016. A three groups had been evaluated clinically and by OAE device (ECHOLAB) to study the DPOAE changing amplitude before and after one month of supplementation of B-complex vitamins to 25 patients in study group (1) have (tinnitus only) and also to 25 patients in study group (2) have (Tinnitus + SNHL) but leaving control group who were a 25 medical staff (No Tinnitus and nor SNHL) without treatment.ResultsIt has been found that among Study group 1 (patients had Tinnitus only), Study group 2 (patients had Tinnitus + SNHL) and the control group: 16 patients (44%), P-value = 0.000 HS; 28 patients (78%) P-value = 0.000 HS; and 0% respectively, they had low Amplitude of DPOAE recorded by OAE device (ECHOLAB). After one month from treatment with Neurobine ampules for study group 1& 2 but not control group (whom receive no treatment), those who got clinical improvement + increase Amplitude of DPOAE (i.e. subjective + objective changes) after treatment were 10 patients (28%) P-value = 0.000 HS in study group1, and two patients (5%) P-value 0.321 NS in study group 2, and there was no changes (zero) among control group.ConclusionsThe uses of DPOAE changing amplitude could be used as a parameter to estimate effect of vitamin B complex on changing the severity of Tinnitus in patients with tinnitus only or those have Tinnitus with SNHL. The supplementation of vitamin B complex could improve the tinnitus severity especially in patients with tinnitus without SNHL.

Influenza vaccine was found to have cross-protective effects against heterologous illnesses, so the role of the influenza vaccination in COVID-19 infection is examined. A total of 1475 participants were separated into 2 groups: 194 individuals who got the influenza vaccination and 1,281 that did not. A comparison of positive COVID-19 testing was the primary outcome. From the two groups, 52 patients who got the influenza vaccination and 50 patients who did not get the vaccination were selected to predict the severity of the COVID-19 infection. The results showed that 13.15% of the participants received the influenza vaccine and no significant difference in the COVID-19 infection rates between the two groups was noted (odds ratio = 1.20, 95% CI = 0.890-1.630, p-value ≤ 0.05). In the vaccinated group, outcomes determined a nonsignificant decrease in the infected odds compared to noninfected, while a significant decrease was shown in the unvaccinated group. Finally, only 1 out of 52 patients (1.9%) in the vaccinated group required oxygen therapy or hospitalization versus 9 out of 50 patients (18%) in the unvaccinated group (odds ratio = 0.08, 95% CI = 0.01-0.7, p-value ≤ 0.05). Influenza vaccination could be linked to better clinical outcomes and a lower COVID-19 severity score, without significant effect on the infection rate.