Background: Ischemic heart diseases are the leading cause of death worldwide. It accounts for (20.07%) of total deaths with a death rate of 279.01 per 100.000 population. Being multifactorial in origin, the causes, diagnosis, prevention, control, and/or treatment of IHD remain active fields of biomedical research with considerable emphasis on the relativity of various risk factors and IHD. Methods: This is a descriptive cross-sectional case-control prospective analytical study to evaluate the hematological and biochemical predictors in ischemic heart disease patients in Shendi locality, River Nile, State Sudan. The study excluded all patients with comorbidities that might affect the results of biomarkers. Results: The mean values of Hb, PCV, RBCs, MCV, MCH, MCHC, RDW in case group were (12.3 g/dl), (37.7%), (4.2x1012/l), (87.9 fl), (28.9 pg), (32.9 g/dl) and (16.5) respectively and mean of TWBCs, Neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet count and MPV of (8.4 x 109 /l), (66.6%), (25%), (5.9%), (2.5%), (0%), (301.9 x 109 /l) and (8.4) respectively. The mean of hsCRP, D.dimer in case group were (5.896 mg/l), (1247.4 ng/ml), respectively. The case group had mean range of urea and creatinine (57.68 mg/dl) and (1.55 mg/dl) respectively, and mean of (Na+), (K+) and (Ca2+) of (136.1 mmol/l), (3.87 mmol/l) and (9.73 mg/dl) respectively. Conclusion: When compared to healthy individuals in the control group, the case group had lower Hb, PCV, red cells indices, serum sodium (Na+), potassium (K+), and calcium (Ca2+) levels. And higher levels of TWBCs, Neutrophil, platelet, MPV, Serum hsC-reative protein, plasma D.dimer, b.urea, and serum creatinine

H syndrome is an autosomal recessive multisystemic disease with a very low prevalence rate, characterized by indurated cutaneous hyperpigmentation, hypertrichosis, and various systemic manifestations. The syndrome is caused by mutations in SLC29A3 gene on chromosome 10q23, encoding for human equilibrative transporter 3 (hENT3). So far, only 100-120 patients with H syndrome have been described in the literature, with predominance among Indian, North-American, and Arab ethnicities. This case report describes the first one of H-syndrome rarities in African ethnicity, a 30-year-old Sudanese male misdiagnosed with rheumatoid arthritis. The patient exhibited more than 90% of the clinical characteristics of H syndrome including obesity, short stature, characteristic hyperpigmented, sclerotic cutaneous plaques with induration and hypertrichosis, inflammatory arthropathy, hallux valgus, flexion deformity of toes, exophthalmos, cardiac anomaly, hypogonadism, and splenomegaly and characteristic histologic findings of dermal fibrosis, histiocytosis, lymphoid aggregation, and vascular proliferation. H syndrome is an extremely rare autoinflammatory condition that has a complex constellation of pleiotropic manifestations with multisystemic involvement. And while further identification and better pathophysiological understanding of H syndrome are needed, physicians worldwide should be vigilant about the overlapping features of H syndrome with many other rheumatological, cutaneous, and genetic diseases.