Myofibroblastoma of the breast is a very rare benign mesenchymal tumor, with relatively few cases described in the literature. We report a case of a large mammary myofibroblastoma appearing as a lipoma on ultrasonography. A 47-year-old woman presented with a slowly growing 12-cm mass over a period of 6 years. Imaging studies suggested a diagnosis of lipoma. Tru-Cut biopsy reveled bland spindle cell lesion consistent with myofibroblastoma, which was confirmed after surgical excision. We are reporting this rare entity and reviewed the literature to emphasize myofibroblastoma as a possible differential diagnosis when evaluating a breast mass.