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Brain diseases such as degenerative (alzheimer's disease), neoplastic disease (brain tumor like sarcoma, glioma) are considered an interesting topic areas in the medical image fusion diagnosis. Pixel-level image fusion techniques are designed to combine multiple/multi-scale input images into a fused image, which is expected to be more informative for human or machine perception as compared to any of the input images.  Since they are difficult to be summarized ; survey paper are characterized by (1) medical image definition , brain diseases challenges , analysis a various techniques for multi-scale image fusion with its own modalities, fusion rule, fusion strategy and dis-advantage ,Whilst used a database of medical images for medical Harvard School (brain diseases) which contains various groups of co-registered multi-modal images including MRI/CT, MRI/PET and PET/SPECT and MRI (T1/T2) images.

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