In this study, we aimed to evaluate the utility of the immune-inflammation index (SII) in estimating the no-reflow phenomenon and short-term cardiovascular prognosis in patients with ST-segment elevation myocardial infarction (STEMI). 723 consecutive patients with STEMI who underwent primary percutaneous coronary intervention (PCI) were enrolled in our study. The receiver-operating characteristics (ROC) curve was used to determine the cut-off value of SII to predict the no-reflow. The multivariate regression analysis analyzed the correlation between no-reflow and SII. The median value of SII was significantly higher in patients with no-reflow in comparison with normal reperfusion [1466 (939–2409) vs 905 (566–1379), p < .001]. The optimal threshold for SII in predicting the no-reflow phenomenon was 1036, with sensitivity and specificity of 70% and 59%, respectively. The area under the ROC curve (AUC) was 0.71 (95% CI, 0.66–0.75, p < .001). In multivariate analysis, SII ≥ 1036 value showed an independent predictive value for the no-reflow (OR = 0.51, 95% CI: 0.29–0.92, p = .02) and the 30-day cardiovascular mortality (OR = 2.37, 95% CI: 1.34–4.19, p = .003). Our results suggest that higher SII levels are independently associated with the no-reflow phenomenon and 30-day mortality in STEMI patients undergoing primary PCI.

Objective: This study aimed to evaluate the utility of the CHA2DS2-VASc score for predicting futile recanalization among patients with acute ischemic stroke (AIS) who underwent endovascular treatment (EVT). Methods: A total of 97 AIS patients who achieved complete or near-complete recanalization after EVT were included in our study. Clinical, angiographic, and laboratory data were analyzed retrospectively. Using the modified Rankin Scale (mRS) at 90 days after the intervention, the patients were divided into two groups, the futile recanalization group (mRS ≥3) and the favorable recanalization group (mRS ≤2). The receiver-operating characteristics (ROC) curve was used to determine the cut-off value of the CHA2DS2-VASc score for predicting futile recanalization.Multivariate stepwise logistic regression analysis analyzed the association between the CHA2DS2-VASc score and futile recanalization risk after EVT. Results: The CHA2DS2-VASc score was significantly higher in patients with futile recanalization compared to patients with favorable recanalization [4 (3-6) vs. 3 (1-4), p=0.002]. A ROC curve analysis revealed that the cut-off value of CHA2DS2-VASc score for predicting futile recanalization was >3, with sensitivity and specificity of 65% and 72%, respectively (Area under curve (AUC), 0.697; 95% Confidence interval (CI):0.580-0.814). In multivariate analysis;the CHA2DS2- VASc score (Odds ratio (OR)=1.637, 95% CI:1.181-2.334, p=0.004) and baseline National Institutes of Health Stroke Scale score (OR=1.217, 95% CI:0.985-1.503, p=0.039) were found independent predictors for futile recanalization after EVT. Conclusion: The CHA2DS2-VASc score can be used as a simple and effective tool to predict futile recanalization in patients with AIS.