The anatomy of the sinonasal area has a very wide rage of anatomical variations. The significance of these anatomical variations in pathogenesis of rhinosinusitis, which is the commonest disease in the region, is still unclear. The aims of the study were to compare the rate of sinonasal anatomical variations with development and severity of chronic rhinosinusitis patients. CT scan of paranasal sinuses images of 99 individuals were retrospectively reviewed. 65 cases of chronic rhinosinusitis (study group) who had undergone endoscopic sinus surgery were compared with 34 cases without chronic rhinosinusitis (control group). Also in study group Lund-Mackay score of the sinus disease were calculated and compared to the rate of related anatomical variations. There were 74 (74.7 %) males and 25 (25.2 %) females with ages ranging from 13 to 70 years (mean 32.2 years). The anatomical variations recorded were: Septal deviation 47 (72.3) in study and 25 (73.5 %) in control group, concha bullosa 27 (41.5 %) in study and 18 (52.9 %) in control group, overpneumatized ethmoid bulla 17 (26.1 %) in study and 14 (41.1 %) in control group, pneumatized uncinate 3 (4.6 %) in study and 3 (8.8 %) in control group, agger nasi 42 (64.6 %) in study and 19 (55.8 %) in control group, paradoxical middle turbinates 9 (13.8 %) in study and 4 (11.7 %) in control group, Onodi cell 6 (9.2 %) in study and 2 (5.8 %) in control group, Haller's cells (infraorbital ethmoid cell) 9 (13.8 %) in study and 7 (20.5 %) in control group. None of these results were statistically significant between study and control group (p [ 0.05). Lund-Mackay score (which was assumed to show the severity of the disease) of the maxillary, ethmoid and frontal sinus were calculated and compared to rate of septal deviation, concha bullosa, agger nasi cells. No significant correlation was conducted (p [ 0.05). The results of study showed no statistically significant correlation between sinonasal anatomical variations and pathologies of the paranasal sinus. Also these anatomical variations did not increase the severity of pre-existing sinusitis significantly. Level of Evidence This is a retrospective cohort study (2b).

Objective. Chronic rhinosinusitis has a negative effect on the quality of life of millions of involved patients. The aim of this study was to assess the effect of endoscopic sinus surgery on the quality of life in patients with chronic rhinosinusitis. Materials and Methods. Twenty-five cases with chronic rhinosinusitis, which were resistant to 12 weeks of medical treatment, underwent Endoscopic Sinus Surgery. Two kinds of health related quality of life (HRQoL) surveys (the Chronic Sinusitis Survey and the Rhinosinusitis Disability Index) were applied to all cases before and at least 6 months after the operation. The LundKennedy endoscopic scoring system was used as an objective evaluation. All analysis was performed using SPSS statistical software. Results. Statistically significant improvements were computed for cases before and after surgery for the Chronic Sinusitis Survey symptom scores (p<0.05). Also, statistically signifi• cant improvements were found for cases using the Rhinosinusitis Disability Index. However, mean changes in endoscopic scores did not statistically correlate with changes in quality of life (p>0.05). Conclusions. Our results showed that endoscopic sinus surgery improves the quality of life in cases with chronic rhinosinusitis. But this improvement did not correlate with the endoscopic scores of the paranasal sinuses.