Synthesis of 2-mercaptobenzothiazole (A 1 ) is performed from the reaction of o-aminothiophenol and carbon disulfide CS 2 in ethanol under basic condition. Compound (A 1 ) is reacted with chloro acetyl chloride to give compound (A 2 ). Hydrazide acid compound (A 3 ) is obtained from the reaction of compound (A 2 ) with hydrazine hydrate in ethanol under reflux in the presence of glacial acetic acid .The reaction of hydrazide acid compound (A 3 ) with ethyl acetoacetate gives pyrazole compound (A 4 ). The new hydrazone compound (A 5 ) was prepared from the reaction of compound (A 3 ) with benzaldehyde. Reaction of compound (A 3 ) with thiourea dissolved in ethanol gave 2-amino thiazole compounds(A 6 ) which was used the reaction with 4-N,N-dimethyl benzaldehyde to yield compound hydrazone (A 7 ).While, the reaction of compound (A 2 ) with urea in the presence of ethanol gave 2-amino oxazole compounds (A 8 ) which was used in the reaction with 3-hydroxy -4 -methoxy benzaldehyde to yield hydrazone (A 9 ). The structures of the prepared compounds were established by spectral ( 1 H-NMR,Elemental analysis (C.H.N-),and FT-IR. In addition to systematic characterization of some active functional groups in these compounds, antibacterial activity (Esheriechia coli, Bacillus subtilis ) for some of the synthesized compounds were evaluated against two types of fugal (Candida albicans ) , the synthesized compounds.

Reaction of the moiety 3-nitro phthalic anhydride with p- Phenylene diamine in (40 ml) acetic acid to give compound (p-amino phenyl)-3-nitro phthalimide (A1).Which that react with different aromatic aldehyde in ethanol absolute to give compounds hydrazone (A2-A5), then react this compounds (A2-A5) with chloro acetyl chloride in presence of TEA by using DMF as solvent to obtain 2-azetidinones (A6-A9).The compounds of all the newly synthesized structures were confirmed by and ,IR, 1H NMR as well as melting point. Some of these new structures showed antimicrobial activity (A7-A8) and anti-bacterial activity (A7-A8).Antibacterial activity of some prepared compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and E.coli (Gram negative). Some the compounds showed high inhibition activity against bacteria and two fungi (Candida albicans) and (Candida tropicalis.).