ARTICLE INFO ABSTRACTThis study was aimed to investigate the levels of plasma sP-selectin and the link between plasma sPselect in levels and the circulating WBC count in patients with AMI. A total of 274 adults (18 years above) patients with clinically suspected acute coronary syndrome who attended in cardiac emergency and admitted in coronary care unit in the department of Cardiology, King George's Medical University, India were enrolled in this study. Among them 248 patients had ECG changes (ST-elevation, ST-depression, T-inversion, appearance of Q-wave) with or without elevated troponin I and treated with anti-plate-let drugs. They were considered as cases (group I). The rest 26 Patients had normal ECG findings, normal cardiac troponin I and did not receive anti-platelet therapy. They were considered as controls (group II). Clinical history, medical reports, findings and information were documented in a pre-designed data sheet with informed and written consent. Blood samples for plasma levels of sP-selectin were obtained in the catheterization laboratory before coronary angiography. Descriptive statistical analyses were performed using SPSS software (version 20, 2008). The study samples were 274 patients, with a mean age of 59.29±11.94 years in cases group and 40.54±19.15 years in control group. Male patient proportion was higher than female in both groups. In cases group, correlation between sP selectin with WBC shows Pearson correlation coefficient (r), and their significance value, sP selectin were directly associated with WBC and demonstrate a significant positive relation (r=0.234, p=0.010). sP-selectin was markedly elevated in cases of AMI. sP-selectin may be involved in modulating the recruitment of circulating WBC during AMI. These findings raise the need for a prospective investigation of sPselectin as a potential reliable clinical tool for rapidly diagnosing AMI.

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