Abstract:-Purpose: This study evaluated the health related quality of life of women with nausea and vomiting of pregnancy attending a maternal clinic in Nigeria Methods: A cross-sectional study was conducted on women with nausea and vomiting of pregnancy(NVP) attending ante-natal clinic at a secondary health facility. The NVP-specific quality of life questionnaire developed for women within 12 weeks of pregnancy was used in this study with some modifications. A total number of 119 women made up the study sample. Data was analyzed using SPSS version 20.Mean scores were presented with standard deviations and domain scores were compared using the mean transformed scores. Results: One hundred and nineteen pregnant women who had NVP at the time of the study participated in the study. The mean total quality of life score was 112.16±33.3 and 53.7% had an average quality of life. Domains on Limitation had a mean transformed score of 27.90 while domain on Fatigue had a mean transformed score of 50.94 depicting better and worse quality of life respectively.Conclusion: The findings showed that women in this locality were able to carry out their normal daily activity irrespective of the impact of nausea and vomiting on them.Members of the healthcare team should however work at improving the quality of life of women with NVP in this locality.