AIM: To report the clinical and therapeutic aspects of dermatofibrosarcoma of Darier and Ferrand (DFS) to the National Hospital of Niamey. MATERIALS AND METHODS: These are 12 patients collected prospectively over three years. RESULTS: It concerns seven men and five women in whom the diagnosis of DFS was made on the basis of histological evidence. The average age was 46.5 years. The tumor was the majority on the trunk (abdominal wall and back) in seven patients or 58.33%. The extension assessment was negative in all patients and all benefited from surgical treatment. This treatment consisted of a wide excision with lateral and deep margins between three and five cm. The recidivism rate is 25% within 17 months. CONCLUSION: DFS is a rare tumor in Niamey. The trunk is its main location. Surgery is the best treatment. And the recurrence rate is still high.