Minor Recurrent Athous Stomatitis (RAS), known as sore that often occurs in oral disease. That characterized by ulcers and pain symptoms for 3-10 days which disrupt the activities that prompt patients seeking medication to relieve these symptoms. RAS etiology is not known clearly, some studies associate it with free radicals. Guava leaves/ Psidium guajava L have much content of bioactive component that are efficacious as analgesic, anti-inflammatory, antimicrobial / antidiarrheal, hepatoprotective and antioxidant. The purpose of this study to determine the effectiveness of antioxidant leaves of Psidium guajava L against Minor RAS by reduction of the diameter of ulcers and pain. This clinical trial was carried out using a single-blind randomized pretest posttest control group method. That consisted of 30 participants who had minor RAS with 15 people got extract gel Psidium guajava L 3% as a treatment group and 15 others received placebo (basic gel) as a control group. Ethanol extract was obtained by maceration method and antioxidant activity test by DPPH (dipheniyl picrylhidrazil) method. This study shows the results of the ethanol extract of leaves of Psidium guajava L has a very strong antioxidant activity with IC50 value of 22.39 ppm. Gel extracts give a a meaningful effect on the healing SAR with statistically significant in the reduction of ulcers diameter p 0.007 by repeated Annova test and a reduction in pain scores p <0.001 by Friedman test. In conclusion, extract Psidium guajava Linn leaves as a high antioxidant content effective promotion the healing process by reduced diameter ulcer and pain of Minor SAR.

Recurrent Aphthous Stomatitis (RAS) is ulcer in the oral mucosa that occur repeatedly with unknown etiologic factors but varied trigger factors and lesion characteristics. The prevalence of RAS still high in community, however pain and the recurrence impact the quality of life both in oral activities and daily activities such as: avoided brushing teeth that it causes poor oral conditions, impaired mastication, swallowing, speaking, feeling uncomfortable, difficulty sleeping and reducing social interaction. The purpose of this study was to determine the frequency distribution of lesion characteristics and the triggering factors for patients with recurrent aphthous stomatitis in USU dental professional students in 2019-2020. This research is a survey study with a cross sectional design. The population is students of the dental profession at the University of North Sumatra in 2019-2020 with a total sample of 62 respondents who were used as research subjects. Measurement of SAR variables using the Recurrent Aphthous Stomatitis Diagnosis (RASDX) questionnaire. The research data was obtained by distributing online questionnaires in the form of a google form. Students who were most affected by SAR were female at 87.1%. The most common type of SAR found was minor at 95.2%, was in the labial mucosa by 72.6%, single ulcers of 95.2%), history of ulcer duration suffered by respondents was around 7-14 days 54.8%, multifactorial triggering factors are genetic, trauma and stress (30,6%) with the most common triggering factor was stress at 93.5%. The characteristics RAS in this research were minor type on the labial mucosa, a single of number and duration of 7-14 days. Based on the trigger factors, it can be concluded that the most common group of 3 multifactor (genetic, trauma and stress) which stress is the most common factors.

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Abstract-Xerostomia is one of the most common complications caused by head and neck cancer radiotherapy. Radiation caused the structure of the salivary glands change thus the saliva production was reduced. This can significantly affect the quality of life of the patients by changing physical, psychological and social function, pain which had an impact on the successful of the radiotherapy treatment. The purpose of this study was to analyze the effect of xerostomia on the quality of life among head and neck cancer patients undergoing radiotherapy at RSUP H. Adam Malik Medan. This was an observational analytic research with cross sectional study approach. 40 subjects of head and neck cancer patients undergoing radiotherapy selected by purposive sampling and data were collected by medical records, anamnesis, and interview. The results of study showed from the 40 subjects, 26 patients (65%) with xerostomia have low quality of life (57.7%), while 14 patients (35%) that not experiencing xerostomia has higher quality of life (85.7%). In conclusion, it is proven that there were significant relationship (p=0.008) between xerostomia and the quality of life among the head and neck cancer patients undergoing radiotherapy.

The decrease in the production of estrogen and progesterone hormones in menopausal women may result in a condition called xerostomia, which is characterized by the subjective perception of dry mouth. This condition can be treated by using a chemical or mechanical stimulus. Therefore, the aims of this study were to identify the chemical content of forest honey as well as to determine the effect of its usage as a 20% mouth rinse on the salivary flow rate in menopausal women with xerostomia at RSGM Universitas of Sumatera Utara. This is an experimental study, which was designed using a single-blind randomized pretest-posttest control group. The inclusion criteria were menopausal women aged 40-65 years old with xerostomia, were not undergoing chemotherapy or radiotherapy treatment for the neck and head, had no systemic diseases, such as uncontrolled diabetes mellitus and kidney failure, and not consuming medication that could affect the normal saliva function. Subjects who were not cooperative during the study procedures were excluded. The sample population consisted of 30 menopausal women with xerostomia, which were divided into two groups. The first group was treated by asking them to gargle with 20% honey solution, while the second group, which served as a control used distilled water. Saliva was collected before and after treatment into a pot for 5 minutes using the spitting method, and the data collected were analyzed with T-test. The results showed that forest honey was rich in diastase enzyme and it increased the salivary flow rate, with p-value=0.000<0.05. Based on these findings, the use of 20% honey solution had a significant effect in increasing the salivary flow rate in menopausal women with xerostomia.