Aim The current study aimed to examine if work‐related factors, psychological variables and selected demographics predict mindfulness among Jordanian nurses. Background Mindfulness has been associated with various work‐related variables. Studies examining mindfulness antecedents in nurses are scarce. Methods A cross‐sectional study was conducted to collect data from 173 nurses currently employed in three major referral hospitals. A demographic questionnaire and instruments to collect data about nursing mindfulness, depression, stress, work–family conflict, and family–work conflict were used. Results The bivariate analysis showed that all study variables combinations were significant except for the correlation between income and mindfulness. The best fit model showed that only four variables significantly contributed to the model: depression, stress, family–work conflict, and educational level. These variables explained 57% of the variance in mindfulness in our sample. Conclusions Depression, stress, family–work conflict and educational levels contributed to mindfulness levels in Jordanian nurses. Implications for nursing management Nurse managers should be aware of the factors that may affect their employees' mindfulness levels and target these factors through the application of evidence‐based interventions to improve nurses' levels of mindfulness, which in turn will mitigate the negative impact of lower levels of mindfulness.