In this study, a computational fluid dynamics (CFD) simulation which adopts the inhomogeneous Eulerian-Eulerian two-fluid model in ANSYS CFX-15 was used to examine the influence of particle size (90 μm to 270 μm) and in situ particle volume fraction (10% to 40%) on the radial distribution of particle concentration and velocity and frictional pressure loss. The robustness of various turbulence models such as the k-epsilon (k-ε), k-omega (k-ω), SSG Reynolds stress, shear stress transport, and eddy viscosity transport was tested in predicting experimental data of particle concentration profiles. The k-epsilon model closely matched the experimental data better than the other turbulence models. Results showed a decrease in frictional pressure loss as particle size increased at constant particle volume fraction. Furthermore, for a constant particle volume fraction, the radial distribution of particle concentration increased with increasing particle size, where high concentration of particles occurred at the bottom of the pipe. Particles of size 90 μm were nearly buoyant especially for high particle volume fraction of 40%. The CFD study shows that knowledge of the variation of these parameters with pipe position is very crucial if the understanding of pipeline wear, particle attrition, or agglomeration is to be advanced.