Indomethacin is one of non-steroidal anti-inflammatory drugs that are commonly used clinically and often cause gastric mucosal injury as a side effect. Generation of reactive oxygen species (ROS) and activation of apoptotic signaling are involved in the pathogenesis of indomethacin-induced gastric mucosal injury. Thioredoxin-1 (Trx-1) is a small redox-active protein with anti-oxidative activity and redox-regulating functions. The aim of this study was to investigate the protective effect of Trx-1 against indomethacin-induced gastric mucosal injury. Trx-1 transgenic mice displayed less gastric mucosal damage than wild type (WT) C57BL/6 mice after intraperitoneal administration of indomethacin. Administration of recombinant human Trx-1 (rhTrx-1) or transfection of the Trx-1 gene reduced indomethacin-induced cytotoxicity in rat gastric epithelial RGM-1 cells. Pretreatment with rhTrx-1 suppressed indomethacininduced ROS production and downregulation of phosphorylated Akt in RGM-1 cells. Survivin, a member of inhibitors of apoptosis proteins family, was downregulated by indomethacin, which was suppressed in Trx-1 transgenic mice or by administration of rhTrx-1 in RGM-1 cells. Trx-1 inhibits indomethacin-induced apoptotic signaling and gastric ulcer formation, suggesting that it may have a preventive and therapeutic potential against indomethacin-induced gastric injury.

Aiming at the fact that large-scale penetration of wind power will to some extent weaken the small signal stability of power systems, in this paper, the dynamic model of a doubly fed induction generator (DFIG) is established firstly, to analyze the impact of wind generation on power oscillation damping. Then, based on the conventional maximum power point tracking control of variable speed wind turbine, a supplementary control scheme is proposed to increase the damping of power system. To achieve best performance, parameters of the damping control are tuned by using a genetic algorithm. Results of eigenvalue analysis and simulations demonstrate the effectiveness of supplementary damping control with fixed wind speed. At last, due to the problem that fluctuation of output power of wind generators would cause the unstable performance of the DFIG damping controller above, a new algorithm that adapts to the wind variation is added to the supplementary damping control scheme. Results of the simulation show that an improved damping control scheme can stably enhance system damping under various wind speeds and has higher practical value.

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