The reactions of Si atoms with NH3 molecules have been studied using matrix-isolation FTIR spectroscopy and density functional theoretical calculations. Silicon atoms reacted with NH3 to form the SiNH3 complex spontaneously in solid argon upon annealing. Mercury arc photolysis with a 290-nm long-wavelength pass filter destroyed the SiNH3 absorptions and produced HSiNH2 absorptions. Full-arc irradiation (250−580 nm) destroyed the HSiNH2 absorptions and produced SiNH absorptions. The potential energy surface along the reaction path leading to the observed products has also been calculated. Similar experiments with Ge gave spectra for the analogous product molecules.

Thieno[2,3‐d]pyrimidinones were reported to act as potent anticancer agents; in this work, a series of new substituted thieno[2,3‐d]pyrimidinone (6) were synthesized via the aza‐Wittig reaction in satisfactory yields. The structures of these compounds were confirmed by elemental analysis, IR, 1H‐NMR, and mass spectral data, and compound 6h was further analyzed by single crystal X‐ray diffraction. Cytotoxic effect of all the compounds was carried out on human breast and lung cancer cell lines (MCF‐7 and SPC‐A‐1, A459). Compound 6f exhibited the best inhibition activities against A459 with IC50 4.1 μM.

To a stirred solution of ethyl 3,4-dihydro-6-methyl-4-oxo-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylate 1 (3 mol), alkyl halide (3.1mmol) in dry 15 mL CH 3 CN, at room temperature, K 2 CO 3 was added. The reaction mixture was stirred at 65-70 o C for 5-6 h and left overnight. The crude product was purified by recrystallization from CH 2 Cl 2 /C 2 H 5 OH (v:v = 2:1) to obtain 2a-2b.

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