Objective: This study aimed to determine the total phenolic content, correlation of it with antioxidant capacity, and peanut hulls as an antiproliferation on Henrietta Lacks (HeLa) cancer cells, which Indonesia has a serious problem in term of cervix cancer.Methods: Peanut hulls were extracted by Soxhlet extraction, ultrasound vibration, and reflux boiling to obtain the best extraction method. The total phenolic content of the ethanol extract and the ethyl acetate fraction was determined using Folin-Ciocalteu method. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to evaluated an antioxidant capacity of both samples. Identification of the isolated flavone was done by ultraviolet spectra and analyzed using liquid chromatography-mass spectrometer. Inhibition of proliferation of HeLa cancer cells was tested for the purified fraction using 3-(4,5-dimethyl thiazole-2-yl)-2, 5-diphenyltetrazolium bromide assay. Results:The results of total phenolic content determination giving 262 (ethanol extract) and 532 (ethyl acetate fraction) mg gallic acid equivalent/g extract, respectively. DPPH assay resulted antioxidant capacity with value of inhibitory concentration 50% (IC 50 ) was 36.36 (ethanol extract) and 18.68 (ethyl acetate fraction) µg/mL, respectively. Identification of isolated flavone resulted an apigenin and indicated moderate potency in inhibiting the proliferation of HeLa cancer cells with IC 50 value of 34 µg/mL. Conclusions:There was a correlation between the total phenolics with antioxidant capacity of the peanut hulls. The isolated flavone is predominated by apigenin. This isolated compound is potential as antioxidant and inhibiting the proliferation of HeLa cancer cells moderately.

Syzygium cumini is one of the endemic plants in Indonesia that has the potential to be developed. The fruit was known to have potential as a diabetes drug. However, very few studies to determine the medicinal potential and identification of compounds of Syzygium cumini wood stem has never been studied before. Therefore, this study aimed to determine the antioxidant activity and content of compounds in Syzygium cumini wood stem ethyl acetate fraction. The crude ethanol extract was prepared from the wood stem powder of Syzygium cumini in ethanol using maceration. Furthermore, it was carried out by the liquid-liquid fractionation process using solvents of different polarity. Antioxidant activity of the crude extract, hexane fraction, and ethyl acetate fraction was determined by spectrophotometric methods using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Analysis of bioactive compounds by using Thin Layer Chromatography (TLC). Identification of compounds functional groups was carried out to support the results of TLC analysis by using Fourier-transform infrared (FTIR). Ethyl acetate fraction showed the highest antioxidant activity (IC50 13,62 µg/mL), followed by ethanol extract (IC50 19,64 µg/mL) and hexane fraction (IC50 61,25 µg/mL). The antioxidant activity of the acetate fraction was lower than that of ascorbic acid with an IC50 value of 2,85 µg/mL. However, this fraction has very strong antioxidant activity. The TLC analysis results showed that the sample was thought to contain an alkaloid, phenolic, flavonoid, and terpenoid. The assumption on agreement with FTIR analysis which showed functional groups were C-H, O-H, N-H, C=O, and C=C aromatics as constituents of these compounds.

At the end of 2019 to the beginning of 2020 the world experienced an extraordinary event, especially in the health sector, in the form of a viral pandemic that attacked globally. This virus is thought to have first appeared in China, precisely in the city of Wuhan, and is thought to have originated from fish and animal markets in the area. At the beginning of its appearance, WHO temporarily named it as 2019 novel coronavirus (2019-nCoV), then WHO announced a new name, namely Coronavirus Disease (COVID-19) which is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2) virus. This is the basis of the problem in encouraging community service activities so that they can actively participate in efforts to prevent COVID-19. The purpose of this online learning spirit development activity is to prevent the spread of Covid-19 which is increasingly happening in Indonesia, so that students can learn well. The method used during this activity is in the form of directly assisting the student learning process by complying with health protocols and assisting online learning. As a result of the learning assistance activities, there has been a significant change from the habits of the surrounding community where stundest are more enthusiastic about learning and no confusion in doing assignments online.

Covid-19 telah ditetapkan sebagai pandemi oleh WHO pada tanggal 9 Maret 2020. Laju penyebaran virus ini masih terus meningkat. Segala upaya dilakukan untuk mencegah penyebaran Covid-19 termasuk penggunaan hand sanitizer. Permintaan hand sanitizer yang semakin melonjak membuat harga jual produk tersebut menjadi lebih tinggi. Selain itu, penggunaan hand sanitizer yang berbahan alkohol terlalu berlebihan akan memicu iritasi pada kulit. Upaya yang dapat dilakukan dengan membuat inovasi produk hand sanitizer yang memanfaatkan bahan alami.  Telah dilakukan pengabdian kepada masyarakat Desa Salamnunggal tentang cara pembuatan hand sanitizer alami dari daun sirih dan jeruk nipis. Kegiatan ini dilakukan bertujuan untuk meningkatkan pemahaman masyarakat tentang pandemic covid-19 yang sedang menjadi permasalahan di negara kita ini dengan cara membuat hand sanitizer yang terdapat di alam yang bisa dimanfaatkan. Kegiatan pengabdian masyarakat ini dilakukan dengan menggunakan metode simulasi dan praktek. Hasil pengabdian menunjukan bahwa pemahaman masyarakat Desa Salamnunggal sangat antusias dan bisa menerapkan hal-hal yang baru yang belum pernah mereka lakukan seperti membuat hand sanitizer dari bahan alam yang bisa dipraktekan di rumah nya masing-masing dan bisa memahami pentingnya kesehatan di masa pandemic ini serta bisa menjaga imunitas tubuh agar tetap sehat.