Gastroesophageal reflux disease is a persistent and widespread condition that affects people of all ages. It has multiple symptoms and has a remarkable effect on the lifestyle and work performance of the person. Objective: To assess the determinants of GERD in patients visiting tertiary care hospitals, Lahore. Methods: A cross-sectional study was conducted at The University of Lahore Teaching Hospital and Jinnah Hospital Lahore for 6 months. Non-probability convenient sampling technique was used to record data of 100 participants by utilizing a validated questionnaire. Results: The results revealed that 40% of males and 60% of females participated in the study. Their BMI showed that 44% of participants were overweight and 18% were obese. 61% of the participants developed GERD complications. Analysis of the questionnaire revealed that 66% of the participants had a basic knowledge of GERD. An important determinant identified was the sedentary lifestyle of 70% of the participants. Conclusion: The study concluded that GERD is found to be more prevalent in patients having obesity, diabetes, hypertension, heart disease, and kidney disease. It deduced that modifiable risk factors can determine the progression of the disease. In this regard, awareness and public health education campaigns would play a promising role in the reduction of disease.