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Exposure to certain solvents in the workplace can cause hearing loss. This study aims to bring attention to the existing literature on the adverse effects of solvents on workers' auditory function in a diverse Asia occupational setting. The literature search used in this study is PubMed and Web of Science. 87% of the selected studies reported that the highest prevalence of hearing loss was from solvents plus noise-exposed group. Evidence shows that interaction between the solvent and the noise could be both additive and synergistic. More epidemiology studies on solvent-induced hearing loss using diverse approaches are warranted in Asia region. Keywords: hearing loss, organic solvent, pure tone audiometry, chemical-induced hearing loss eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI:

Introduction: The World Health Organisation (WHO) has estimated an increasing number of occupational hearing loss. In Malaysia, there is high pervasiveness of hearing loss and hearing impairment among manufacturing workers. Ototoxicity Prevention and Management Intervention (PMI) is not yet established in the majority of countries, including Malaysia. This work aims to investigate the ototoxicity PMI from international guidelines and global reports. Method: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 flow diagram was adopted for item selection. Two large data sets were used: (1) published, peer-reviewed articles obtained through two search strategies (PubMed and Web of Science); and (2) grey literature. Results: Sixteen items were identified and were categorised into a triad of approaches; exposure-based, knowledge-based, and clinical-based approaches. Conclusion: The way forward rises from this study suggested that an effective ototoxicity PMI is needed in occupational settings where ototoxic chemical (ototoxicants) exposure occurs. Therefore, more efforts should be geared toward ototoxicity PMI especially in developing countries.