Determination of heavy metals is enormously important to determine the condition of the aquatic environment in terms of chemical pollution. In this study, a preliminary determination of heavy metal concentrations in sediment, water, and some macroinvertebrates in several sampling sites along Tawi-Tawi Bay, Philippines, was undertaken to have an initial status of heavy metal pollution in the area. Results revealed that the average concentration of heavy metals followed the order of Fe > Zn > Mn > Pb > Cu > Ni > Cd for sediment, Pb > Zn > Cu > Ni > Fe > Cd > Mn for seawater, Fe > Zn > Mn > Cu > Pb > Ni > Cd for spider conch (Lambis lambis Linnaeus, 1758), and Fe> Zn > Pb > Ni > Mn > Cu > Cd for sea cucumber (Holothuria scabra, Jaeger, 1833). However, all these determined heavy metals were within the safety limits set by WHO, US (EPA and FDA), and EMA. This study suggests that despite the anthropogenic activities in the coastal areas, heavy metal contamination in Tawi-Tawi Bay has not exceeded the safety limits.