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Diabetic foot ulcer (DFU) is one of the major complications of diabetes and results in the amputation of lower limb if not treated timely and properly. Despite the traditional clinical approaches used in DFU classification, automatic methods based on a deep learning framework show promising results. In this paper, we present several end-to-end CNN-based deep learning architectures, i.e., AlexNet, VGG16/19, GoogLeNet, ResNet50.101, MobileNet, SqueezeNet, and DenseNet, for infection and ischemia categorization using the benchmark dataset DFU2020. We fine-tune the weight to overcome a lack of data and reduce the computational cost. Affine transform techniques are used for the augmentation of input data. The results indicate that the ResNet50 achieves the highest accuracy of 99.49% and 84.76% for Ischaemia and infection, respectively.

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Background: Complex prediction from interaction network of proteins has become a challenging task. Most of the computational approaches focus on topological structures of protein complexes and fewer of them consider important biological information contained within amino acid sequences. Objective: To capture the essence of information contained within protein sequences we have computed sequence entropy and length. Proteins interact with each other and form different sub graph topologies. Methods: We integrate biological features with sub graph topological features and model complexes by using a Logistic Model Tree. Results: The experimental results demonstrated that our method out performs other four state-ofart computational methods in terms of the number of detecting known protein complexes correctly. Conclusion: In addition, our framework provides insights into future biological study and might be helpful in predicting other types of sub graph topologies.

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