Objective: To assess the knowledge and attitude of nurses towards radiation protection In Maiduguri metropolis. Methods:A descriptive cross-sectional survey design was used. A quota sampling technique was used to draw a total of 188 registered nurses from three tertiary hospitals in Maiduguri metropolis; University of Maiduguri Teaching Hospital (UMTH), Federal Neuro-Psychiatric Hospital Maiduguri (FNPH), and State Specialist Hospital Maiduguri (SSH) participated in the study. Data was obtained using a 14-item self completion questionnaire that was administered to nursing staff of these hospitals. The questionnaire was divided into 2 sections. Section A; on demographic data and Section B; on knowledge and attitude. Data obtained were analyzed using SPSS version 18.0 and descriptive statistics was used for the analysis.Results: There were more female than male participants with a ratio of 1.09:1. Majority of the nurses (74%) were below the age of forty (40). Most of the nurses 68 (36.2%) had diploma as their highest qualification followed by 61 (32.4%) certificate holders. The level of knowledge on radiation was found to be good and positive attitude towards radiation during ward/theater radiography. Conclusion:Findings of this study revealed that nurses within Maiduguri metropolis had good knowledge of ionizing radiation, although their attitude towards radiation protection during ward/theater radiography is still less than required.