Musculoskeletal disorders are one of the most commonly occurring life style related disease which significantly affect the quality of life. Other than age, body mass, nutritional factors and joint injuries, the occupation related stress and load also have substantial effect of this disease. In the present paper we have conducted a survey on Musculoskeletal diseases among academicians of our college and presented the results after statistical analysis. A Nordic based questionnaire modified suitably for this study was used. The results suggested a higher prevalence of neck and lower back pain among all faculties. The correlation studies suggested a higher positive relationship between joint pain and professional factors like prolonged standing, long term use of computers etc, which was even higher than effect of age and body weight.

: Melasma is one of the most common causes of hyperpigmentation and is a prevalent cosmetic concern for patients. Tranexemic acid is an effective mode of treatment available in both oral and topical forms. : To evaluate and compare the therapeutic effectiveness of topical and oral tranexamic acid for the treatment of melasma. A total of 84 patients who presented to dermatology OPD with melasma were divided into two groups, namely A and B. Group A patients were treated with oral tranexamic acid 250 mg twice daily, and patients in Group B were treated with topical 5% tranexamic acid with follow-up every 4 weeks until 3 months. Among the oral treatment and topical patient groups, a statistically significant difference in the mean percentage of reduction in MASI score from baseline was observed at 12 weeks (61.31±9.48 for oral vs 52.64±8.03 for topical) with p<0.05. Systemic side effects like abdominal pain, nausea, and oligomenorrhea were observed with oral tranexemic acid, while topical side effects like erythema, skin irritation, and xerosis were observed with topical tranexemic acid treatment. Oral tranexamic acid gave a more promising result when compared to topical tranexamic acid. Despite having GI disturbances with oral tranexamic acid, it had more patient compliance and could be a promising therapeutic approach for melasma.

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Female pattern hair loss (FPHL) is explained by decrease in hair fiber production and their eventual miniaturization. It is considered a counterpart of male androgenetic alopecia but the role of androgens in its pathogenesis is yet to be proven. To evaluate the trichoscopic features in females with patterned hair loss. Inclusion and exclusion criteria were applied and 37 cases were enrolled in our study. Detailed history and clinical examination were done to establish the diagnosis. Trichoscopic examination was done after taking consent in diagnosed cases. On trichoscopy, hair diameter variability, peri pilar sign, white dots, scalp pigmentation and focal atrichia was observed in 62.2%, 62.2%, 40.5%, 45.9% and 40.5% respectively. Most common trichoscopy finding observed was peri pilar sign and hair diameter variability in 23/37 females. Definitive diagnosis of FPHL is difficult to be established solely on the basis of clinical examination. Thus, trichoscopy serves as a non-invasive tool to ascertain the diagnosis in these patients.

The metabolic syndrome is the term used to describe a constellations of metabolic derangements that includes insulin resistance, hypertension, Dyslipidemia, central or visceral obesity, type 2 DM & accelerated cardiovascular disease. An oxidative imbalance is responsible for the development of both metabolic syndrome & vitiligo. In the present study we have evaluated the association of metabolic syndrome with Vitiligo.In this observational cross-sectional study we selected 40 subjects attending skin OPD with age matched 40 controls and assessed the waist circumference, blood pressure, serum triglyceride level, cholesterol and high-density cholesterol along with Fasting blood glucose level at tertiary care Hospital. A detailed history including age, gender, diabetes mellitus, hypertension, smoking and onset of vitiligo was taken. The MetS criteria were defined by National Cholesterol Education Program Adult Treatment Panel III 2005 (ATP III) guidelines.We identified metabolic syndrome in 15 subjects with vitiligo and 6 subjects without vitiligo. The P value came 0.022 which is statistically significant. Active vitiligo, segmental vitiligo and increased duration of vitiligo were determined to be independent predictors of metabolic syndrome.The risk of developing metabolic syndrome is increased in patients of vitiligo. Screening and the close follow up of the patients of vitiligo with clinical feature such as in unstable, segmental vitiligo with increased duration is necessary for the early diagnosis of the metabolic syndrome to reduce the morbidity & mortality of the patients