Background: Dry Weight (DW) is the lowest weight after dialysis, and patients with lower weight usually have symptoms of hypotension and shock. Several clinical-based approaches have been presented to assess dry weight of hemodialysis patients. However, these traditional methods all depend on special instruments and professional technicians. Objective: In order to avoid this limitation, we want to find a machine-independent way to assess dry weight, so we collected some clinical influencing characteristic data and constructed a Machine Learning-based (ML) model to predict the dry weight of hemodialysis patients. Methods: In this paper, 476 hemodialysis patients' demographic data, anthropometric measurements, and Bioimpedance spectroscopy (BIS) were collected. Among them, these patients' age, sex, Body Mass Index (BMI), Blood Pressure (BP) and Heart Rate (HR) and Years of Dialysis (YD) were closely related to their dry weight. All these relevant data were used to enter the regression equation. Multiple Kernel Support Vector Regression-based on Maximizes the Average Similarity (MKSVRMAS) model was proposed to predict the dry weight of hemodialysis patients. Result: The experimental results show that dry weight is positively correlated with BMI and HR. And age, sex, systolic blood pressure, diastolic blood pressure and hemodialysis time are negative correlated with dry weight. What's more, the Root Mean Square Error (RMSE) of our model is 1.3817. Conclusion: Our proposed model could serve as a viable alternative of dry weight estimation for hemodialysis patients, thus providing a new way for the clinic.

Dry weight is the normal weight of hemodialysis patients after hemodialysis. If the amount of water in diabetes is too much (during hemodialysis), the patient will experience hypotension and shock symptoms. Therefore, the correct assessment of the patient’s dry weight is clinically important. These methods all rely on professional instruments and technicians, which are time-consuming and labor-intensive. To avoid this limitation, we hope to use machine learning methods on patients. This study collected demographic and anthropometric data of 476 hemodialysis patients, including age, gender, blood pressure (BP), body mass index (BMI), years of dialysis (YD), and heart rate (HR). We propose a Sparse Laplacian regularized Random Vector Functional Link (SLapRVFL) neural network model on the basis of predecessors. When we evaluate the prediction performance of the model, we fully compare SLapRVFL with the Body Composition Monitor (BCM) instrument and other models. The Root Mean Square Error (RMSE) of SLapRVFL is 1.3136, which is better than other methods. The SLapRVFL neural network model could be a viable alternative of dry weight assessment.

Dry weight (DW) is an important dialysis index for patients with end-stage renal disease. It can guide clinical hemodialysis. Brain natriuretic peptide, chest computed tomography image, ultrasound, and bioelectrical impedance analysis are key indicators (multisource information) for assessing DW. By these approaches, a trial-and-error method (traditional measurement method) is employed to assess DW. The assessment of clinician is time-consuming. In this study, we developed a method based on artificial intelligence technology to estimate patient DW. Based on the conventional radial basis function neural (RBFN) network, we propose a multiple Laplacian-regularized RBFN (MLapRBFN) model to predict DW of patient. Compared with other model and body composition monitor, our method achieves the lowest value (1.3226) of root mean square error. In Bland-Altman analysis of MLapRBFN, the number of out agreement interval is least (17 samples). MLapRBFN integrates multiple Laplace regularization terms, and employs an efficient iterative algorithm to solve the model. The ratio of out agreement interval is 3.57%, which is lower than 5%. Therefore, our method can be tentatively applied for clinical evaluation of DW in hemodialysis patients.