A metal-free
oxidative rearrangement was explored for the synthesis
of 1,2-diaryl diketones by utilizing α,β-unsaturated diaryl
ketones and I
2
/TBHP in good to high yields. The reaction
proceeds via oxidative aryl migration, followed by C–C bond
cleavage. A simple and high-yielding protocol was developed for the
synthesis of a wide range of 1,2-diaryl diketones, which are the backbone
for a variety of medicinally important molecules.
A highly efficient, metal free rapid protocol studied mechanistically the oxidation of primary and secondary amines to their corresponding carbonyl compounds using PhI(OAc)2 and catalytic TEMPO to provide diverse products in excellent yields.
A visible light‐rose bengal‐TBHP mediated, controlled oxidation of N‐substituted 1,2,3,4‐tetrahydroisoquinolines is developed for the synthesis of 3,4‐dihydroisoquinolin‐1(2H)‐ones and isoquinolin‐1(2H)‐ones. The present method feature's a broad substrate scope, good functional group tolerances, and the products were prepared in good to excellent yields. The developed methodology further demonstrated in the synthesis of isoindolo[2,1‐b] isoquinolin‐5(7H)‐one (topoisomerase‐I inhibitor).
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