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To determine the causes of failure of an artificial temporomandibular joint implant, one must study the magnitude and location of the maximum stresses under physiological loading. In this study, we analyzed the stresses in a commercially available TMJ implant, the bone (i.e., mandible), and the bone-implant interface using a finite element software package. Both titanium and Co-Cr-Mo/Vitallium metals as well as bones with various degrees of osteoporosis were studied. The results of the analysis showed that the maximum stresses occurred at the location of the first screw hole (closest to the condyle) of the implant. In addition, the highest microstrains were observed in the bone adjacent to the first screw hole. The results of our study have potential clinical benefit in terms of improved implant design and hence better performance.