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With the increasing analysis of saving environment, the researchers demonstrated much effort to replace toxic chemicals with environmentally benign ones. Eutectic mixtures are those solvents that fulfill the criteria of green solvents. The synthesis of organic compounds in the chemical and pharmaceutical industries makes it necessary to find unconventional solvents that cause no harmful impact on health parameters. This review showed that using deep eutectic mixture-based solvents to overcome the hazardous effects of harmful volatile organic solvents over the past few years has gained much more appeal. In most applications, deep eutectic mixtures aRecent Advances in Utilization of Deep Eutectic Solvents: An Environmentally Friendly Pathway for Multi-component Synthesisre used for a solvent or co- solvent role, as they are easy to use, easy dissolution of reactants, and non-evaporative nature. However, deep eutectic mixtures have also been investigated as catalysts, and this dual functionality has much scope in the future, as a significantly less range of deep eutectic mixtures is utilized for this.

Isoxazole and its derivatives derived from natural resources are very few. However, they have several applications in pharmaceutical industries, including antimicrobial, antitumor, anticancer, antifungal, and antibacterial activities. As a result, this research aimed to design a novel one-pot green approach to synthesize new oxazole derivatives. The derivatives were further explored for their antibacterial and antioxidant activities together with their DFT analysis. Characterization of newly synthesized moieties was done by IR, 1 H NMR, 13 C NMR, CHN analysis, & single-crystal X-ray Crystallography. Further, these compounds were examined for their antibacterial potential by using Gentamycin as a standard drug against S. aureus and E. colibacterial strains. The derivatives 4a, 4c, 4d, 4f, 4j, and 4k possessed excellent antibacterial potential against former, while 4c and 5 showed the highest activity against thelater one.The derivatives were also analyzed for their antioxidant activities by using free radical scavenging (ABTS. & DPPH assays), and Total antioxidant capacity (TAC). Here also, 4a, 4d, 4e, 4k, 4l, 4m, and 5 exhibited the most promising results. Finally, the density functional theory (DFT) analysis was achieved by using the B3LYP methodology with a 6-311+G(d,p) basis set to study the electronic structure of molecules and analysis of chemical reactivity descriptors such as hardness (η), Mulliken electronegativity (χ), chemical potential (μ) and electrophilicity (ω). These properties were calculated from the levels of the predicted frontier molecular orbitals and their energy gap.

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